·糖尿病与脂质代谢·

　　新诊断2型糖尿病患者血清SPARC及FGF21水平相关性的研究

　　贾国瑜 邸阜生 王璐 余红艳 李雪粉

　　【摘要】 目的 了解新诊断T2DM患者血清SPARC及FGF21水平，并探讨二者间相关性。 方法 选取85例新诊断T2DM患者为T2DM组，健康体检者82名为NGT组，分别测定两组生化指标及SPARC、FGF21水平，应用相关分析分析SPARC与FGF21的相关性。 结果 T2DM组的SPARC及FGF21水平均高于NGT组(P均<0.01)，两组血清SPARC水平与FGF21水平高度相关，r分别0.783、0.648(P<0.01)。多元逐步回归分析结果表明FGF21和HOMA-IR是血清SPACR水平的独立影响因素。 结论 FGF21及SPARC均可能抑制脂肪形成、改善IR上发挥作用。

　　【关键词】 糖尿病，2型;FGF21;SPARC

　　新诊断2型糖尿病患者 血清SPARC 及 FGF21水平 相关性的研究

　　Association between the serum SPARC and FGF21 levels in newly diagnosed T2DM patients JIA Guo-yu, DI Fu-sheng, WANG Lu, et al. Department of Endocrinology and Metabolism, The Third Central Hospital of Tianjin, Tianjin 300170, China

　　Corresponding author: DI Fu-sheng, E-mail: ????

　　【Abstract】 Objective To investigate the serum fibroblast growth factor 21 (FGF-21) and secreted protein acidic and rich in cysteine (SPARC) levels in T2DM patients to male sure of the association between FGF21 and SPARC. Methods Eighty-five newly diagnosed T2DM patients were put into the T2DM group and 82 healthy people formed a NGT group. ELISA was used to evaluate the levels of FGF21 and SPARC of the two groups. The correlation analysis was carried out to see the association between them. Results The level of FGF21 and SPARC was significantly higher in the T2DM group (P<0.05) than that in the NGT group (NGT), and in both groups the level of SPARC was highly associated with FGF21, r=0.783 vs r=0.648, (P<0.01). Multivariate regression analysis showed that FGF21 and HOMA-IR were the independent related factors influencing plasma SPARC levels. Conclusions Both FGF21 and SPARC function to inhibit the adipogenesis and improve the insulin resistance.

　　【Key words】 Diabetes mellitus, type 2; Serum Fibroblast Growth Factor 21 (FGF21); Secreted protein acidic and rich in cysteine (SPARC)