·糖尿病与脂质代谢·

　　正常人群甲状腺功能与脂肪代谢的相关性分析

　　张皎月 陈璐璐 孙晖 郑涓 胡祥 王素星 陈婷

　　【摘 要 】 目的 研究正常人群中血清促甲状腺激素(thyroid stimulating hormone, TSH)与脂肪代谢的关系。 方法 对武汉1322名正常人群进行体格检查、血TSH测定及肝脏超声检查。 结果 超重(A)组血清TSH水平高于对照(B)组。女性TSH > 2.5 mIU/L(B)组体重、体重指数(body mass index, BMI)、WC、体脂含量明显高于TSH ≤ 2.5 mIU/L(A)组。体脂含量、BMI是TSH的独立影响因素。TSH不是影响非酒精性脂肪肝患病的独立危险因素。 结论 女性正常范围内的血清TSH与肥胖密切相关;血清TSH与非酒精性脂肪肝的患病风险无关。

　　【关键词】 促甲状腺激素;肥胖;血脂;非酒精性脂肪肝

　　A study of the relationship between thyroid function and lipid metabolism in euthyroid subjects

　　ZHANG jiao-yue, CHEN Lu-lu, SUN Hui, ZHENG Juan, HU Xiang, WANG Suxing, CHEN Ting. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

　　Correspondence author: CHEN Lu-lu, Email: cheria_chen@126.com

　　[Abstract] Objective To explore the relationship between serum thyroid stimulating hormone (TSH) level and lipid metabolism in euthyroid subjects. Methods 1322 subjects were carried out physical, laboratory and liver ultrasonography examination. Results Serum TSH level was significantly higher in overweight than in control group. Levels of body weight, BMI, waist circumference and percentage of body fat were increased in TSH > 2.5 mIU/L compared to TSH ≤ 2.5 mIU/L in women. Percentage of body fat and BMI contributed significantly to the variance of TSH. TSH level was not the independent risk factor of nonalcoholic fatty liver disease. Conclusions Serum TSH in normal range was significantly correlated with obesity in women. And the change of TSH would not increase the prevalence of nonalcoholic fatty liver disease.

　　[Key words] thyroid stimulating hormone; Obesity; lipid; Nonalcoholic fatty liver diseaseStudy on the relationship between thyroid function and lipid metabolism in euthyroid subjects ZHANG Jiao-yue, CHEN Lu-lu, SUN Hui, et al. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

　　Correspondence author: CHEN Lu-lu, Email: cheria_chen@126.com

　　【Abstract】 Objective To explore the relationship between serum thyroid stimulating hormone (TSH) level and lipid metabolism in euthyroid subjects. Methods The 1322 subjects were enrolled in the trial. Physical, laboratory, and liver ultrasonography examinations were carried out for all of them. Results Serum TSH level was significantly higher in overweight (A)group than in control (B)group. Levels of body weight, BMI, waist circumference, and percentage of body fat were increased in TSH > 2.5 mIU/L women (B)group compared with those in TSH ≤ 2.5 mIU/L women (A)group. Percentage of body fat and BMI contributed significantly to the variance of TSH. TSH level was not the independent risk factor of non-alcoholic fatty liver disease. Conclusions Serum TSH in normal range is significantly correlated with obesity in women. And the change of TSH will not increase the prevalence of non-alcoholic fatty liver disease.

　　【Key words】 Thyroid stimulating hormone (TSH); Obesity; Blood lipid; Non-alcoholic fatty liver disease