·糖尿病足病与下肢血管病变·

　　【摘要】 目的 观察微量动脉泵持续股动脉输注前列地尔治疗糖尿病足病(DF)的疗效。 方法 T2DM并发足病患者56例随机分为微量泵治疗(A)组和对照(B)组，A组给予微量泵持续股动脉输注前列地尔,B组予静脉输注,均持续3~7 d。观察两组冷感或红肿减轻例数及侧支循环建立例数。 结果 治疗后A组患者病变肢体皮温升高多于B组，比较差异有统计学意义[(2.52±0.70)℃ vs (0.07±0.26)℃，t=17.61,P=0.002]。A组患肢溃疡愈合情况好于B组(P=0.001)。 结论 微量动脉泵持续股动脉输注前列地尔治疗Foutain 3级及3级以上DF，可使患肢血管建立侧支循环，改善足部血供。

　　【关键词】 糖尿病足病;前列地尔;微量动脉泵

The observation of therapeutic efficacy of continuous infusion of alprostadil through femoral artery pump for diabetic foot disease JIANG Cheng-xia ,CAO Yue-yong ,PAN Jun-jiang,et al.Department of Endocrinology,The Second People's Hospital of Yibin City,Yibin 644000,China

　　【Abstract】 Objective To observe the therapeutic efficacy of continuous intra-femoral artery infusion of alprostadil by femoral artery pump for diabetic foot disease. Methods 56 patients with type 2 diabetes mellitus plus diabetic foot disease were divided into treatment group and control group.The treatment group received continuous infusion of alprostadil through femoral artery pump and control group received intravenous injection of alprostadil for 3～7 days.We observed the number of cases with improvement of cold feeling ，redness and swelling as well as collateral circulation establishment in treatment group versus control group. Results After treatment,the skin temperature were significantly higher in the treatment group than in control group [(2.52±0.70)℃ vs (0.07±0.26)℃,t=17.61,P=0.002].The treatment group is better than controlgroup in ulcer healing(P=0.001). Conclusion The treatment to diabetic foot disease of Foutain 3 level and more than 3 levels by continuous infusion of alprostadil by femoral artery pumps can promote collateral circulation establishment in patients with DFD,and improve the blood supply of foot.

　　【Key words】 Diabetic foot;Alprostadil;Micro-artery-pump