·胰岛素抵抗及其相关疾病·

　　【摘要】 目的 探讨血清睫状神经营养因子(CNTF)水平与T2DM和肥胖的相关性及临床意义。 方法 44名糖耐量正常(NGT组)者和44例新诊断T2DM(T2DM组)患者按BMI又各自分为超重(Ob)和正常体重(Nob)亚组。ELISA法测定血清CNTF水平。 结果 T2DM组血清CNTF的浓度较NGT组降低(P<0.05)。相关分析显示，T2DM组中CNTF与TC、HbA1c、FBG、HOMA-IR呈负相关(r=-0.293、-0.343、-0.279、-0.328，P<0.01或P<0.05)。HOMA-IR(β=-0.627，P<0.05)是血清CNTF的独立相关因素。 结论 T2DM患者CNTF水平降低，与TC、HbA1c、FBG、HOMA-IR呈负相关，HOMA-IR是CNTF独立相关因子。

　　【关键词】CNTF;超重;糖尿病,2型

Clinical significance of serum CNTF level in T2DM patients GAO Man-yun,FAN Qing-tao,CHENG Xing-bo, et al. Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China

Corresponding author: FAN Qing-tao, E-mail: fgt2000@163.com

　　【Abstract】Objective To evaluate the association of serum ciliary neurotrophic factor (CNTF) with T2DM and overweight. Methods The 44 newly diagnosed T2DM patients and 44 NGT subjects were involved in the study and the two groups were subdivided into normal weight (Nob) and overweight (Ob) subgroups respectively according to BMI

　　【Key words】Ciliary neurotrophic factor (CNTF); Overweight; Diabetes mellitus, type 2