·胰岛素抵抗及其相关疾病·

　　【摘要】 目的 探讨不同糖耐量患者HbA1c与IR的相关性。 方法 291例研究对象行75 gOGTT，根据结果分为T2DM、IGR和正常糖耐量(NGT)组，分析各组HbA1c与IR相关指标的关系。 结果 T2DM组WHR、FPG、2 hPG、HbA1c、LDL-C、FIns和胰岛素抵抗指数(HOMA-IR)高于IGR组，HDL-C、胰岛素分泌指数(HOMA-β)和ISI低于IGR组(P<0.05或P<0.01)。T2DM组HbA1c与TG、HOMA-IR呈正相关(r=0.17，P=0.03;r=0.19，P=0.02)，与HOMA-β呈负相关(r=﹣0.28，P=0.00)。IGR组HbA1c与HOMA-β呈负相关(r=﹣0.32，P=0.02)。NGT组HbA1c与HOMA-IR、HOMA-β、ISI无相关性(P>0.05)。 结论 T2DM组HbA1c、HOMA-IR高于IGR、NGT组，不同糖耐量组HbA1c与IR均呈正相关。

　　【关键词】糖化血红蛋白;胰岛素抵抗;糖尿病，2型;糖调节受损;正常糖耐量

The study of correlation between hemoglobin A1c and insulin resistance in different glucose tolerance patients WU Yuan-yuan,LI Jun,LI Si-yuan,et al.Shihezi University School of Medicine, Shihezi 832002, China

Corresponding author: LI Jun, E-mail:xjlijun@163.com

　　【Abstract】 Objective To observe the correlation between HbA1c and IR in different glucose tolerance patients. Methods OGTT were carried out in 291 patients and the results were categorized into T2DM, IGR and normal glucose tolerance (NGT) groups. The correlation between HbA1c and IR index were analyzed among three groups. Results WHR, FPG, 2 hPG, HbA1c, LDL-C, FIns, HOMA-IR were significantly higher in T2DM group than in IGR group (P<0.05 or P<0.01), HDL-C, insulin secretion index (HOMA-β) and insulin sensitivity index (ISI) were significantly lower in T2DM group than in IGR group (P<0.05 or P<0.01). HbA1c was positively correlated with TG and HOMA-IR (r=0.17, P= 0.03;r=0.19, P=0.02) and negatively with HOMA-β(r=﹣0.28, P=0.00) in T2DM group. HbA1c was negatively with HOMA-β(r=﹣0.32, P=0.02) in IGR group. HbA1c was not correlated with HOMA-IR, HOMA-β, ISI in NGT group (P>0.05 ) . Conclusion HbA1c and HOMA-IR are significantly higher in T2DM group than in IGR and NGT groups. HbA1c is positively correlated with IR in groups with different glucose tolerance.

　　【Key words】Hemoglobin A1c(HbA1c);Insulin resistance(IR);Diabetes mellitus，type 2;Impaired glucose regulation(IGR);Normal glucose tolerance(NGT)