【摘要】 目的 观察高尿酸血症(HUA)降低血UA水平治疗能否改善IR及胰岛β细胞功能。 方法 将60例无症状HUA患者随机等分为两组，治疗组采用低嘌呤饮食并口服别嘌醇治疗，对照组未接受治疗，观察治疗前后BMI、SBP、DBP、TG、TC、LDL-C、FPG、FIns、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)等指标变化。 结果 治疗前两组UA、BMI、SBP、DBP、TG、TC、LDL、FPG、FIns、HOMA-IR、HOMA-β差异均无统计学意义(P均>0.05);治疗组治疗后UA较治疗前降低差异有统计学意义(P<0.01)，对照组治疗前后UA差异无统计学意义(P>0.05);两组治疗后BMI、SBP、DBP、TG、TC、LDL、FPG、FIns、HOMA-IR、HOMA-β较治疗前差异均无统计学意义(P均>0.05)。 结论 通过饮食与别嘌醇控制HUA并不能改善IR及胰岛β细胞功能。

　　【关键词】 高尿酸血症;血尿酸;胰岛素抵抗;胰岛β细胞功能

　　Effect of reducing serum uric acids on insulin resistance and islet β cell functions in patients with hyperuricemia DING Li-xin, HE Wei-Li, JI Xuan. Department of Endocrinology, Chang’an Hospital, Xi’an 710016, China

　　【Abstract】 Objective To observe whether the treatment of reducing serum uric acids (UA) for hyperuricemia (HUA) could improve the insulin resistance (IR) and islet β cell functions of the patients. Methods Sixty HUA patients without clinical symptoms were randomized into treatment and control groups. The treatment group had low purine diet and oral allopurinol, while the control group received no treatment. The indices of body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), fasting insulin (FIns), insulin resistance (HOMA-IR), and islet β cell functions (by homeostasis model assessment, HOMA-β) were observed. Results There was no significant difference in the levels of UA, BMI, SBP, DBP, TG, TC, LDL-C, FPG, FIns, HOMA-IR, and HOMA-β between two groups before treatment (P all>0.05). The UA level after treatment was significantly lower than before treatment in the treatment group (P<0.01), and the difference was statistically significant (P>0.05). The difference in the UA level before and after treatment was not statistically significant in the control group (P>0.05). Comparing with before treatment, the levels of BMI, SBP, DBP, TG, TC, LDL, FPG, FIns, HOMA-IR, and HOMA-β after treatment were not significantly different in both groups (P all>0.05). Conclusion The low purine diet and oral allopurinol for HUA control is not helpful for improving IR and islet β cell functions of the patients.

　　【Key Word】 Hyperuricemia (HUA); Serum uric acids (UA); Insulin resistance (IR); Islet β cell functions