【摘要】 目的 探讨T2DM患者Ca199水平与血糖、IR和胰岛β细胞功能之间的关系。 方法 入选T2DM患者165例，分别以HbA1c 10.1%、FPG 8.31 mmol/L、胰岛素抵抗指数2.7、胰岛功能指数22.1为界,分为高HbA1c组(HH组)和低HbA1c组(LH组);高FPG组(HF组)和低FPG组(LF组);胰岛素抵抗组(IR组)和胰岛素敏感组(SR组);胰岛β细胞功能正常组(BN组)和胰岛β细胞功能减退组(BW组)，比较各组Ca199水平。 结果 HH组Ca199水平高于LH组(26.75 vs 16.68 U/ml, P<0.05)。Spearman相关研究显示，Ca199与HbA1c、FPG呈正相关(P<0.05)，与IR、胰岛β细胞功能无相关性(P>0.05);多元逐步回归分析显示，HbA1c是Ca199的主要影响因素。 结论 T2DM患者Ca199水平与血糖状态密切相关。

　　【关键词】Ca199;空腹血糖;HbA1c;胰岛素抵抗;胰岛β细胞功能

　　Influencing factors on Ca199 in patients with type 2 diabetes mellitus HE Shuang-tao, LIU Jun, ZHOU Lian-hua. Department of Endocrinology and Metabolism, the Affiliated Fifth People’s Hospital and Jinshan Hospital of Shanghai Fudan University

　　【Abstract】 0bjective To investigate the relations of Ca199 level with blood glucose, insulin resistance, and βcell function in patients with type 2 diabetes mellitus. Methods The 165 hospitalized patients with type 2 diabetes were enrolled. They were divided into high glycosylated hemoglobin group (HH) and low glycosylated hemoglobin group (LH) at the level of HbA1c 10.1%, high fasting blood glucose group (HF) and low fasting blood glucose group (LF) at the level of 8.31mmol/L, insulin resistance group (IR) and insulin sensitivity group (SR) at the level of 2.7, norm β cell function group (BN) and hypo β cell function group (BW) at the level of 22.1. The Ca199 level among the four groups was compared. Results The Ca199 level of the HH group at 26.75U/ml was significantly higher than the LH group at 16.68U/ml (P<0.05). Spearman relation analysis showed that the Ca199 level was positively correlated with HbA1c and FPG (P<0.05), but not correlated with IR and β cell function (P>0.05). Multiple stepwise regression analysis showed that HbA1c was the main risk factor for Ca199. Conclusion The Ca199 level in patients with type 2 diabetes closely correlated with the state of blood glucose.

　　【Key words】 Ca199; Fasting blood glucose; Glycosylated hemoglobin (HbA1c); Insulin resistance; β cell function