【摘要】 目的 探讨T2DM患者颈动脉内中膜厚度(cIMT)与肾小球滤过率(GFR)的相关性;方法 随机选取年龄>45岁的血压控制在140/90mmHg以下的T2DM患者143例，以cIMT 0.9mm为标准将其分为cIMT<0.9mm(IMT正常组)和cIMT≥0.9mm(IMT增厚组)，比较两组间年龄、病程、早期肾病(MAU)所占比例、GFR及各项生化指标的差异;结果 IMT增厚组的年龄、糖尿病病程、MAU所占比例明显高于IMT正常组，而GFR则明显低于IMT正常组(P<0.05)。多元逐步回归分析显示cIMT与年龄、糖尿病病程呈正相关，而与GFR呈负相关。结论 随着动脉硬化的不断进展，GFR呈不断下降趋势且独立于传统的心血管危险因素参与早期动脉硬化的发生与发展。

　　【关键词】糖尿病, 2型;颈动脉内中膜厚度; 肾小球滤过率

　　Relationship between carotid intima-media thickness and glomerular filtration rate in type 2 diabetic patients JIA Yan-kun, HAN Li-ping, XIE Yun .Department of Neuropathy .Metabolic Diseases Hospital ,Tianjin Medical University, Key Lab of Hormones and Development, Ministry of Health and Tianjin, Tianjin 300070,China

　　Corresponding author: XIE Yun,E-mail:tjxieyun0108@sina.com

　　【Abstract】 Objective To investigate the correlation between carotid intima-media thickness(cIMT) and glomerular filtration rate (GFR) in type 2 diabetic patients. Methods 143 patients whose age is above 45 were selected and the patients’blood pressure should be controlled below 140/90mmHg. Divided the patients into two groups :the normal group(cIMT<0.9mm) and the thick group (cIMT≥0.9mm) by the standard of cIMT 0.9mm. Compared the age , duration，MAU frequency, GFR and biochemical indexes between them. Results cIMT thick group’s age, duration and MAU frequency is much higher than the indexes of cIMT normal group, and the GFR of the thick group is much lower than the one of the normal group(P<0.05). No statistical difference has been found in biochemical indexes such as fasting glucose and lipids between two groups. Multiple stepwise regression analysis showed cIMT has a positive correlation with age, duration, and a negative correlation with eGFR. Conclusions With the development of the atherosclerosis, GFR inclines to decrease and contributes to the occurance and development of early-stage atherosclerosis.

　　【Key Words】Diabetic mellitus， type 2;carotid intima-media thickness, glomerular filtration rate