【摘要】 目的 探讨不同剂量吡格列酮(PIO)对STZ DM大鼠体内氧化应激的影响。方法 STZ腹腔注射建立DM大鼠模型。成模DM大鼠随机分为模型组和不同剂量PIO组,并设正常对照(NC)组,4周和8周时腹主动脉取血检测血清丙二醛(MDA)水平和超氧化物歧化酶(SOD)活性。 结果 4周时，模型组较NC组MDA含量显著升高，SOD活性显著下降(P均<0.01);PIO各组较NC组差异无统计学意义(P>0.05)。8周时，模型组、PIO各组较NC组MDA含量显著升高，SOD活性显著下降(P均<0.01)，PIO20 mg·kg-1·d-1和30 mg·kg-1·d-1组较模型组MDA含量显著降低，SOD活性显著升高(P均<0.01)，PIO10 mg·kg-1·d-1组较模型组差异无统计学意义(P>0.05)。 结论 PIO可减轻DM大鼠体内氧化应激，且该作用具有一定的剂量依赖性。

　　【关键词】 超氧化物歧化酶;丙二醛;氧化应激;吡格列酮

　　Effect of different dosages of piogitazone on the level of oxidative stress in STZ-induced diabetic rats WANG Yue-fen, XING Yan, YE Shan-dong. Department of Endocrionology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China

　　Corresponding author: YE Shan-dong, E-mail: ysd196406@163.com

　　【Abstract】 Objective To investigate the effect of different dosages of pioglitazone (PIO) on the oxidative stress in STZ-induced diabetic rats. Methods Diabetic models were established by a peritoneal injection of streptozotocin (STZ). All the diabetic rats were randomized into model group and PIO different dosage groups. The healthy rats served as a normal control group. At the 4th week and 8th week, the abdominal aortic blood was obtained for measuring serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) level. Results At the 4th week, the MDA level increased and the SOD activity decreased significantly in the model group, compared with the NC group (P<0.01), but those in all the PIO groups were not statistically different from those in the NC group (P>0.05). At the 8th week, the MDA level increased and the SOD activity decreased significantly in the model group and all the PIO groups, compared with the NC group (P<0.01). The MDA level decreased and the SOD activity increased significantly in the PIO 20mg·kg-1·d-1 and 30mg·kg-1·d-1 groups, compared with the NC group (P<0.01). There was no statistical difference between the PIO 10mg·kg-1·d-1 group and the model group (P>0.05). Conclusion Piogitazone can alleviate oxidative stress in vivo with a dose dependent manner in STZ-induced diabetic rats.

　　【Key words】 Superoxide dismutase (SOD); Malondialdehyde (MDA); Oxidative stress; Pioglitazone (PIO)