来自:中国糖尿病资讯网 编辑:editor|点击数:|2012-09-21
【摘要】目的 探讨中国汉族人T2DM患者ACE基因缺失型(DD型)基因多态性和DN的关系。方法 采用Meta分析系统评价ACE DD基因型与DN的相关关系。使用Cochrane协作组提供的Revman5.0.23软件合并DD基因型频率统计量Peto OR值及其95%CI。结果 共纳入29个符合条件的病例对照研究,DN组2295例,非DN对照组2197例。结果示Peto OR值1.93 [95%CI(1.68,2.23)],合并统计值Z=9.06,P<0.01。敏感性分析提示该Meta分析结果较为可靠。漏斗图呈对称性分布,提示无明显的发表偏倚。结论 中国汉族人DN与ACE 插入/缺失多态性显著相关,ACE DD基因型是DN的危险因子。
【关键词】糖尿病,2型;糖尿病肾病;血管紧张素转换酶;多态现象, 遗传;Meta分析
Relationship between diabetic nephropathy and angiotensin converting enzyme gene deletion polymorphism in Chinese Han population: a systematic review JIA Hai-yan, WEN Shi-lin.Department of Endocrinology, Henan Provincial People’s Hospital, 450003 Zhengzhou, China
【Abstract】 Objective To observe the association between the angiotensin-converting enzyme gene polymorphism (insertion/deletion) and diabetic nephropathy among Chinese type 2 diabetic Han population. Methods A systematic review and meta-analysis were performed to evalue the association of the ACE DD gene type and DN. Revman 5.0.23 was employed for Meta-analysis. Peto OR and 95%CI were analyzed. Results 29 eligible studies were selected in this systematic review, including 2295 patients with DN and 2197 diabetic patients without DN. The results of the meta-analysis showed that Peto OR=1.93(95%CI 1.68,2.23), Z=9.06(P<0.00001). Sensitive analysis showed the results of this meta analysis were reliable. The funnel plot showed symmetry. Conclusions There is association between ACE gene I/D polymorphism and the diabetic nephropathy in type 2 Chinese diabetic patients. DD gene type may be one risk factor of type 2 diabetic nephropathy in Han Chinese.
【Key words】Diabetes mellitus, type 2;Diabetic nephropathies; angiotensin-converting enzyme;Polymorphism, gentic ;Meta-analysis
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