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糖尿病大鼠消化道的生物力学和形态重构

来自:中国糖尿病资讯网  编辑:editor|点击数:|2012-05-31

  ·糖尿病基础研究·

  作者单位:100029北京,卫生部中日友好医院(沙洪、赵东、陈朋民);丹麦奥尔胡斯大学(赵静波);中医科学研究院广安门医院(刘桂芳、甄仲);中丹大学(HANS GREGERSEN)

  通讯作者:赵静波

  糖尿病大鼠消化道的生物力学和形态重构

  沙洪 赵静波 刘桂芳 赵东 陈朋民 甄仲 HANS GREGERSEN

  【摘要】目的观察链菌脲酶素(STZ)诱导的糖尿病大鼠,其消化道的形态学和生物力学特性是否发生了重构。方法用(STZ)复制糖尿病大鼠模型(DM)组,用注射生理盐水作为正常对照(NC)组。定期检测血糖和体重。造模成功60 d后,测量管壁的湿重、壁厚、展开角、残余应变和分析其应力应变关系。结果DM组大鼠食管和各个肠段的湿重与体重的比值、壁厚、展开角和内外残余应变的绝对值,明显高于NC组(P<0.05 和 P<0.01) 。DM组食管和结肠的周向和轴向的管壁硬度与正常对照组比较,均有统计学意义的增加(P<0.05),而空肠表现为周向管壁硬度的增加(P<0.05)。结论STZ诱导的糖尿病大鼠的食管,小肠,结肠和直肠的形态学和生物力学均发生了重构,其管壁的重构可能与糖尿病病人的胃肠功能紊乱有关。

  【关键词】糖尿病大鼠;消化道;形态学;应力-应变;零应力状态

  doi:10.3969/j.issn.1006-6187.2012.05.019

  Biomechanical and morphological remodelings of gastrointestinal tract in STZ-induced diabetic ratsSHA Hong, ZHAO Jing-bo, LIU Gui-fang, et al. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China

  Corresponding author: ZHAO Jing-bo

  【Abstract】ObjectiveTo investigate the morphological and biomechanical remodelings of gastrointestinal(GI) tract in streptozotocin(STZ) induced diabetic rats.MethodsThe rat models were established with STZ injection and the rats in the control group were injected with normal saline. The blood glucose and body weight were regularly measured. Sixty days after the successful modeling, the wet weight, thickness, developing angle, and residual strain of the GI tract were measured and its stress-strain relation was analyzed.ResultsThe absolute value of ratio of the wet weight of the esophageal and intestinal segments to the body weight, thickness, opening angle, and residual strain of inner and outer walls of GI tract was significantly higher in diabetes group than in the control group(P<0.05 and P<0.01). Compared with the control group, the stiffness of the esophageal and colonic walls in circumferential and longitudinal directions increased in DM group (P<0.05), while that of the jejunum in circumferential direction increased(P<0.05).ConclusionThe experimental diabetes induces the morphological and biomechanical remodeling of GI tract of rats. The remodeling of the walls of GI tract is likely related to the gastrointestinal disorders in the diabetic patients.

  【Key words】Diabetes rats; Gastrointestinal tract; Morphology; Stress-strain; Zero stress state

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