·药物研究动态·

　　作者单位：100853北京，解放军总医院内分泌科

　　地特胰岛素在糖尿病治疗中的应用与体重控制

　　母义明

　　【摘要】肥胖与糖尿病的发生发展密切相关。超重和肥胖可造成T2DM患者全因死亡率和心血管疾病风险增加，因而有效的体重控制对于T2DM患者十分重要。地特胰岛素是一种新型的基础胰岛素类似物，可有效控制血糖和降低低血糖风险，同时具有独特的体重优势，与其他基础胰岛素相比可显著减少体重增加，且在BMI较大的人群中体重优势更加明显。因而地特胰岛素对于糖尿病患者是一种理想的基础胰岛素。

　　【关键词】体重;糖尿病，2型;基础胰岛素;地特胰岛素

　　doi:10.3969/j.issn.1006-6187.2012.05.024

　　Clinical application of insulin detemir in the treatment of diabetes and its superiority in weight controlMU Yi-ming. General Hospital of People’s Liberation Army, Beijing 100853, China

　　【Abstract】ObjectiveThe incidence and development of type 2 diabetes is closely related to obesity. Moreover, overweight or obesity in patients with type 2 diabetes is associated with increasing risk of overall mortality and cardiac vascular disease, thus effective weight management in patients with type 2 diabetes is critical. Insulin detemir is a new basal insulin analogue, which can effectively control blood glucose level and reduce the risk of hypoglycemia. Meanwhile, it has a unique benefit in weight control by inducing less weight gain than other basal insulins, and its superiority in weight control in those who have increased body mass index (BMI) is more significant. Therefore, insulin detemir is the ideal basal insulin for patients with diabetes.

　　【Key words】Weight; Diabetes, type 2; Basal insulin; Insulin detemir