·胰岛素抵抗及其相关疾病·

　　基金项目：国家自然科学基金面上项目青年基金(30800539)，中央高校基本科研业务费专项资金资助

　　作者单位：210008南京大学医学院附属鼓楼医院内分泌科

　　通讯作者：毕艳，E-mail：biyan@nju.edu.cn

　　空腹血糖与胰岛β细胞功能及胰岛素敏感性关系的研究

　　杨慧杰 毕艳 童国玉 孙婧 陈莹莹 杨东辉 朱大龙

　　【摘要】目的评估FPG与胰岛β细胞功能及IS之间的关系。方法采用多阶段分层整群随机抽样方法对江苏省1277例人群进行研究，根据OGTT分为NGT、IFG、IGT、IGR、T2DM组。IS用ISI及1/HOMA-IR评价;β细胞功能用经IS校正的处置指数DI(包括DI0、DI30、DI120 )评估。结果同NGT组ISI、DI0、DI30、DI120相比，IGT组分别下降25.2%、17.1%、37.2%、12.5%;IFG组分别下降23.5%、65.4%、37.6%、37.1%;IGR组分别下降42.7%、70.1%、56.5%、38.1%;T2DM组分别下降44.7%、83.4%、76.0%、66.0%。结论在正常糖耐量阶段，随着FPG升高，IS和胰岛素分泌有下降趋势，两者共同促进FPG的升高。

　　【关键词】糖尿病，2型;β细胞功能;胰岛素敏感性;空腹血糖

　　doi:10.3969/j.issn.1006-6187.2012.05.001

　　Relationship of fasting plasma glucose with β-cell function and insulin sensitivityYANG Hui-jie, BI Yan, TONG Guo-yu, et al. Department of Endocrinology, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Nangjing 210008, China

　　Corresponding author: BI Yan, E-mail：biyan@nju.edu.cn

　　【Abstract】ObjectiveTo evaluate the change of β-cell function and insulin sensitivity when fasting plasma glucose (FPG) increased.Methods1277 subjects from Jiangsu province were randomized into NGT, IFG, IGT, IGR and T2DM groups by 75g OGTT. Insulin sensitivity was measured by ISI and 1/HOMA-IR. β-cell function adjusted by insulin sensitivity was assessed by DI at basal DI0, early-phase DI30 and total DI120.ResultsCompared with the NGT group, the ISI, DI0, DI30, DI120 were decreased by 25.2%, 17.1%, 37.2%, and 12.5% respectively in the IGT group; 23.5%, 65.4%, 37.6%, and 37.1% respectively in the IFG group; 42.7%, 70.1%, 56.5%, and 38.1% respectively in the IGR group; 44.7%, 83.4%, 76.0%, and 66.0% respectively in the T2DM group.ConclusionBoth the impairment of β-cell function and insulin sensitivity start at the low point of FPG within the normoglycemic range and contribute to the deterioration of FPG.

　　【Key words】Diabetes mellitus, type 2; β-cell function; Insulin sensitivity; Fasting plasma glucose