·讲座·

　　宋丹丹 邹大进

　　基金项目:国家自然科学基金资助项目(30900708)

　　作者单位：200433上海，第二军医大学长海医院内分泌科

　　通讯作者：邹大进，E-mail：zwjd22@medmail.com.cn

　　【提要】代谢正常肥胖(MHO)是近年来备受关注的一类肥胖亚群，以肥胖但高胰岛素敏感性为特征，占肥胖群体的20%~30%。由于某些保护机制存在，MHO人群与以往所说的“高危肥胖”人群，在临床表现、炎症、代谢谱、治疗及预后等方面均截然不同，深入探索其代谢保护机制及临床参数的纵向变化对肥胖研究和卫生保健工作意义重大。本文从流行病学、界定标准、保护机制、研究前景等方面全面概括MHO的研究进展，旨在推进科研及临床工作者对这一重要肥胖亚型的认识。

　　【关键词】代谢正常肥胖;胰岛素敏感性;高危肥胖

　　doi:10.3969/j.issn.1006-6187.2012.01.024

　　Research progress of the metabolically healthy but obeseSONG Dan-dan, ZOU Da-jin.Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

　　Corresponding author: ZOU Da-jin, E-mail: zwjd22@medmail.com.cn

　　【Summary】Metabolically Healthy but Obese (MHO) individuals are a subset of obesity concerned in recent years and characterized by obesity and high insulin sensitivity, accounting for 20%-30% of obese population. MHO individuals are distinguished from those "at-risk obese" in aspects of clinical manifestations, inflammation, metabolic profiles, treatment and prognosis. Further study of its metabolic protection mechanisms and clinical longitudinal changes is of great significance for obesity research and health care. This review provided a comprehensive overview of MHO in aspects of epidemiology, standard definition, protection mechanisms and research prospects, for promoting an advancing understanding of this important obesity subtypes.

　　【Key words】Metabolically healthy but obese; Insulin sensitivity; At-risk obese