·国际研究动态·

　　洪珊珊 摘译 钱荣立 审校

　　译者单位：100034北京，本刊编辑部

　　【提要】Besser REJ， Knight BA， Shepherd MH等的"Urinary C-peptide creatinine ratio (UCPCR) is a practical outpatient tool for identifying HNF1A/HNF4A MODY from long duration type 1 diabetes"(Diabetes Care,2011,34:286-291 )一文比较了成人中HNF1A/4A MODY、T1DM、T2DM中的UCPCR水平，证实了UCPCR是可用于鉴别HNF1α/HNF4α MODY与长期T1DM的非侵入性门诊诊断工具。并指出对于从病程>5年的T1DM和MODY的鉴别，UCPCR可用于确定是否需要基因检测。

　　【关键词】糖尿病，1型;HNF1A/HNF4A MODY;尿C肽肌酐比值

　　Urinary C-peptide creatinine ratio (UCPCR) is a practical outpatient tool for identifying HNF1A/HNF4A MODY from long duration type 1 diabetesHONG Shan-shan, QIAN Rong-li. Editorial Department of Chinese Journal of Diabetes, Beijing 100034, China

　　【Summary】 Besser REJ, Knight BA, Shepherd MH, et al compared stimulated UCPCR in adults with HNF1A/4A MODY, type 1 diabetes, and type 2 diabetes in "Urinary C-peptide creatinine ratio (UCPCR) is a practical outpatient tool for identifying HNF1A/HNF4A MODY from long duration type 1 diabetes"(Diabetes Care,2011,34:286-291 ),and concluded UCPCR was a noninvasive outpatient tool that can be used to discriminate HNF1A and HNF4A MODY from long-duration type 1 diabetes. To differentiate MODY from type 1 diabetes of >5 years’ duration, UCPCR could be used to determine whether genetic testing is indicated.The essential parts were tanslated in the following article.

　　【Key words】Diabetes Mellitus, type 1; HNF1A/HNF4A MODY; Urinary C-peptide creatinine ratio (UCPCR)