·糖尿病基础研究·

　　赵海燕 王勇 吴力武 马永平

　　基金项目：教育部留学回国人员科研启动基金资助项目(2005年)

　　作者单位：750021银川，北方民族大学生物科学与工程学院

　　【摘要】目的研究甘草黄酮(LF)对T2DM大鼠血糖、血脂等生化指标的影响。方法将实验大鼠分为模型组(DM)、高剂量给药组(HLF)、低剂量给药组(LLF)、正常对照组(Con)和正常给药组(CLF)。分别以LF或溶剂灌胃，5周后检测实验大鼠的空腹血糖、血脂等生化指标及肝体比、肾体比和脂体比。结果高剂量LF(300 mg·kg-1·d-1)显著降低了糖尿病大鼠的FBG、TG、TC、LDL-C、FFA、TNF-α、瘦素、肝体比和肾体比, 并显著提高了糖尿病大鼠的T-AOC、ISI和脂体比。结论LF具有降低糖尿病大鼠血糖、调节脂代谢紊乱的作用，并可显著改善胰岛素抵抗。

　　【关键词】甘草黄酮;糖尿病，2型;胰岛素抵抗;血糖;血脂

　　doi:10.3969/j.issn.1006-6187.2012.01.021

　　Effect of licorice flavonoids on blood glucose, blood lipid and other biochemical indicators in type 2 diabetic ratsZHAO Hai-yan, WANG Yong, WU Li-wu, et al.School of Life Sciences and Technology, North University for Minorities, Yinchuan 750021, China

　　【Abstract】ObjectiveTo study the effect of licorice flavonoids (LF) on fasting blood levels of glucose (FBG), lipids, insulin, adipokines and other biochemical indicators. MethodsThe type 2 diabetic rat model was replicated by feeding high-fat and high-sugar diet combined with low-dose streptozotocin (STZ) injection. The diabetic rats were divided into model group (DM), high-dose LF treatment group (HLF) and low-dose LF treatment group (LLF). Other 20 normal rats were divided into control group (Con) and control treatment group (CLF). Rats in different groups were administered LF(100mg or 300mg·kg-1·d-1) or solvent (propylene glycol) respectively. Five weeks later, the levels of fasting levels of glucose (FBG), triglycerides (TG), total cholesterol (TC), free fatty acids (FFA), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total antioxidation capability (T-AOC), insulin (Ins), tumor necrosis factor alpha (TNF-α) and leptin were examined. Insulin sensitivity index (ISI), liver index, kidney index and the relative weight of abdominal adipose tissue were calculated. ResultsThe high-dose LF (300mg·kg-1·d-1) treatment significantly decreased the levels of FBG, TG, TC, LDL-C, FFA, T-AOC, TNF-α, leptin, liver index and kidney index, and increased the levels of T-AOC, ISI and the relative weight of abdominal adipose tissue. Compared with high-dose treatment, low dose of LF was less effective. Conclusion LF significantly decreases the blood glucose level, improves the lipid metabolic disorders and ameliorates insulin resistance in type 2 diabetic rats.

　　【Key words】Licorice flavonoids; Diabetes mellitus, type 2; Insulin resistance; Blood glucose; Blood lipid