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两种促胰岛素分泌剂对血糖漂移的影响

来自:中国糖尿病资讯网  编辑:admin|点击数:|2011-10-21

  ·糖尿病临床研究·

  李舸 李海峰

  作者单位:528305广东省佛山市顺德桂洲医院内四科(李舸);广东省佛山市顺德容奇医院内二科(李海峰)

  【摘要】 目的 交叉对比分析瑞格列奈和格列齐特的动态血糖图谱,观察比较血糖波动系数、低血糖发生率和餐后血糖峰值。 方法 T2DM患者52例,分别应用瑞格列奈或格列齐特,常规检查血糖。采用交叉设计,应用瑞格列奈组患者改用格列齐特,应用格列齐特组患者改用瑞格列奈,改用前后分别予动态血糖监测72 h。原有饮食运动及联用口服药物不变。以用瑞格列奈为研究组,用格列齐特为对照组,对比分析两组血糖波动系数、低血糖发生率和餐后血糖峰值。 结果 经2周洗脱期、8周剂量调整期、2周剂量维持期、3 d监测期后的结果显示:应用瑞格列奈比应用格列齐特血糖控制更平稳,动态血糖图谱表现为血糖波动系数小,低血糖次数少,低血糖时间比少(P<0.01),餐后血糖峰值低(P<0.05)。 结论 本研究条件下,应用瑞格列奈比应用格列齐特似可减少血糖漂移幅度。

  【关键词】动态血糖监测系统;血糖漂移;瑞格列奈; 格列齐特

  doi:10.3969/j.issn.1006-6187.2011.10.015

  The effect of repaglinide versus gliclazide on glycemic excursion amplitude detected with continuous glucose monitoring system

  LI Ge, LI Hai-feng. Department of Endocrinology, Guizhou Hospital, Shunde District, Guangdong Foshan 528305, China

  【Abstract】 Objective With the continuous glucose monitoring system, glycemic excursions amplitudes were compared between treatments with repaglinide versus gliclazide in type 2 diabetic patients. MethodsRandom and crossover trial were designed. Totally 104 CGMS data of 52 patients were analyzed. The glycemic excursions were compared in patients treated with repaglinide versus gliclazide. ResultsThe trial consisted of a 2 weeks of wash out followed by an 8 weeks of dosage regulation and a 2 week of dose maintenance periods. The data of continuous glucose monitoring system (CGMS) showed that the frequency of hypoglycemia and amplitude of glycemic excursion were decreased remarkably in group treated with repaglinide compared with that of gliclazide (P<0.01). ConclusionGlycemic excursion amplitude is effectively improved in type 2 diabetic patients treated with repaglinide.

  【Key words】Continuous glucose monitoring system; Glycemic excursion; Repaglinide; Gliclazide

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