·糖尿病临床研究·

　　施广德 张晓兰 黄文龙

　　作者单位：214400江阴，东南大学医学院附属江阴医院内分泌科

　　【摘要】 目的 对T2DM患者予以胰岛素联合艾塞那肽的治疗，观察艾塞那肽对T2DM的疗效。 方法 将入选的60例T2DM患者随机分为A组和B组，各30例。A组使用预混胰岛素治疗，B组在A组方案基础上加用艾塞那肽治疗，随访4个月，比较两组患者血糖控制、胰岛β细胞功能以及血脂、体重等变化情况。 结果 两组患者血糖均得到良好控制，B组△2hPG低于A组(P<0.05)，△2hC-P、△HOMA-β则高于A组(P<0.05)。另外，B组患者BMI、TG较治疗前明显下降。 结论 使用艾塞那肽可改善T2DM患者的血糖和胰岛β细胞功能，减少胰岛素使用剂量，降低体重。

　　【关键词】糖尿病，2型; 艾塞那肽; β细胞功能

　　doi:10.3969/j.issn.1006-6187.2011.10.014

　　Therapeutic effects of exenatide in type 2 diabetic patients

　　SHI Guang-de, ZHANG Xiao-lan，HUANG Wen-long. Department of Endocrinology, Jiangyin Hospital Affiliated Hospital of Medical College of Southeast University, Wuxi 214400, China

　　【Abstract】 Objective To evaluate the therapeutic effects of exenatide on type 2 diabetes. Methods 60 patients with type 2 diabetes (T2DM) were randomly divided into two groups: group A(premixed insulin injection) and group B (premixed insulin plus exenatide injection). The glucose level, β-cell function, lipid profiles and body weight were measured at baseline and 4 months after treatment. Results Excellent control of blood glucose was achieved in both groups.△2hPG, △2hCP, and △HOMA-β were more improved in group B than in group A (P<0.05). BMI and TG in group B were decreased significantly after treatment as compared with pre-treatment. Conclusions Exenatide improves glucose control and β-cell function in T2DM patients, and decreases insulin dosage and weight loss.

　　【Key words】Diabetes mellitus,type 2; Exenatide; β-cell function