【摘要】  目的  测定上海地区T2DM患者血清超氧化物歧化酶（SOD）水平，分析其影响因素。 方法  选取T2DM患者（T2DM组）452例和健康体检者（NC组）60名，测定血清SOD、C-P和HbA₁c水平,及FPG、LDL-C、TG和TC水平。 结果  T2DM组血清SOD水平低于NC组[（132.25±21.43） vs （156.64±18.77） U/ml，P＜0.05]。在T2DM组中，男性血清SOD水平高于女性[（135.38±22.62） vs （129.36±19.88） U/ml，P＜0.01]；49岁以下各年龄段男性血清SOD水平均高于女性（P＜0.01），而50岁以上各年龄段男性与女性血清SOD水平比较，差异无统计学意义（P＞0.05）；男性患者中，≤29岁年龄段血清SOD水平最高，≥70岁年龄段SOD水平最低，各年龄段水平比较，差异有统计学意义（F=24.56,P＜0.001）；女性患者中，≤29岁年龄段血清SOD水平最高，≥70岁年龄段SOD水平最低，各年龄段水平比较，差异有统计学意义（F=13.75,P＜0.001）；T2DM患者血清SOD水平与年龄呈负相关（r=-0.531,P＜0.001）；Logistic逐步回归分析显示，血清SOD水平降低与HbA₁c浓度异常相关。  结论  T2DM患者血清SOD水平低于正常人，且受性别、年龄、血糖、血脂等因素的影响。

【关键词】  糖尿病，2型；超氧化物歧化酶；影响因素 

Serum superoxide dismutase level and its related factors in patients with type 2 diabetes in Shanghai

 【Abstract】  Objective  To investigate serum superoxide dismutase (SOD) level and its related factors in patients with type 2 diabetes (T2DM) in Shanghai, China.  Methods  452 T2DM patients(T2DM group) and 60 heal-thy people (NC group) were recruited in this study. Serum SOD was measured by Pyrogallol colorimetry, serum C-peptide by chemiluminescence method, and HbA₁c by high performance liquid chromatography.  Result  Overall， serum SOD in T2DM group was lower than that in NC group [(132.25±21.43) vs （156.64±18.77) U/ml, P＜0.05]. In T2DM group, men had higher serum SOD level than women [(135.38±22.62) vs （129.36±19.88） U/ml, P＜0.01], especially in subjects with age≤49 years. In male patients, subjects aged ≤29 had the highest serum SOD concentration and subjects aged ≥70 had the lowest, there were significant differences between every age group (F=24.56, P＜0.001). In female patients, subjects aged ≤29 had the highest serum SOD concentration and sub-jects aged ≥70 had the lowest, there were significant differences between every age group (F=13.75, P＜0.001). We observed a significant correlation between serum SOD concentration and age (r= -0.531, P＜0.001). Logistic regression analysis showed that the decrease of serum SOD was related to HbA₁c.  Conclusion  Serum SOD level in T2DM is significantly lower than in healthy people, and influenced by gender, age, blood glucose and cholesterol.

【Key words】 Diabetes mellitus, type 2; Superoxide dismutase（SOD）;Influence factor