女性2型糖尿病患者血尿酸水平与体质指数、血压和血脂关系的研究

来自：中国糖尿病杂志编辑：黄莹芝叶山东|点击数：|2016-03-04

【摘要】 目的探讨女性T2DM患者不同血尿酸(SUA)水平与BMI、血压和血脂的相关性。方法选取女性T2DM患者429例，其中绝经前76例，绝经后353例。根据SUA水平将患者分为正常SUA（NUA）组和高尿酸血症（HUA）组。比较两组BMI、血压和血脂的变化。结果本研究中，HUA患者57例（13.29%），其中绝经前7例，绝经后50例。绝经前，HUA组BMI[(27.90±5.13) vs (24.08±3.38) kg/m²]、SBP[(142.71±12.60) vs (128.96±15.62) mmHg]、TC[(6.64±1.84) vs (4.47±1.14) mmol/L]、LDL-C[(4.65±1.73) vs (2.80±1.09) mmol/L]较NUA组高（P＜0.05）。绝经后，HUA组年龄[(68.60±8.92) vs (64.56±8.47) 岁]、病程[(12.94±6.69) vs (9.58±6.96) 年]、BMI[(26.64±3.04) vs (24.18±2.99) kg/m²]、TG[(2.88±2.44) vs (1.84±1.27) mmol/L]较NUA组高（P＜0.05），FPG[(8.90±4.49) vs (10.49±5.95)mmol/L]、HbA₁c[(7.64±1.79)% vs (9.06±2.40)%]、HDL-C[(0.93±0.23) vs (1.19±0.33)]较NUA组低（P＜0.05）。多元线性回归分析显示，BMI与绝经前患者HUA存在相关性，BMI、TG、HDL-C与绝经后患者HUA存在相关性。结论绝经前T2DM患者SUA水平与体重增加有关。绝经后T2DM患者SUA水平与血脂异常和体重增加有关。

【关键词】 糖尿病，2型；血尿酸；高血压；血脂异常；体质指数

Correlation of serum uric acid with BMI, blood pressure and lipids in women with T2DM

【Abstract】 Objective To analyze the association between serum uric acid（SUA）and BMI, blood pressure and lipids in women with type 2 diabetes (T2DM). Methods The clinical data of 429 T2DM were collected, in-cluding 76 premenopausal women and 353 postmenopausal women. These patients were divided into normal SUA (NUA) group and hyperuricemia (HUA) group according to the SUA levels. BMI, blood pressure and lipids of two groups were compared. Results The prevalence of hyperuricemia was 13.29% (n=57, 7 premenopause and 50 postmeno-pause) . Among premenopausal women, compared with NUA group, patients in group HUA showed higher BMI [(27.90±5.13)vs(24.08±3.38)kg/m², P＜0.05], SBP [(142.71±12.60)vs(128.96±15.62)mmHg，P＜0.05], TC [(6.64±1.84)vs(4.47±1.14)mmol/L，P＜0.05], and LDL-C [(4.65±1.73)vs(2.80±1.09)mmol/L，P＜0.05]. Among postmeno-pausal women, patients with HUA showed higher age [(68.60±8.92)vs(64.56±8.47)years，P＜0.05], course [(12.94±6.69)vs(9.58±6.96)years，P＜0.05], BMI [(26.64±3.04)vs(24.18±2.99)kg/m²，P＜0.05], and TG [(2.88±2.44)vs(1.84±1.27)mmol/L，P＜0.05]; and lower FPG [(8.90±4.49)vs(10.49±5.95)mmol/L，P＜0.05], HbA₁c [(7.64±1.79)%vs(9.06±2.40)% ，P＜0.05], and HDL-C [(0.93±0.23)vs(1.19±0.33)mmol/L，P＜0.05] than those in group NUA. Multiple linear regression analysis showed that BMI was independently associated with SUA in premenopausal T2DM women. BMI, TG and HDL-C were independently associated with SUA in postmenopausal T2DM women. Conclusion SUA level among premenopausal women is related to increased BMI, which is related to dyslipidemia and increased BMI among postmenopausal women.

【Key words】 Diabetes mellitus，type 2；Serum uric acid (SUA)；Hypertension；Dyslipidemia；Body mass index（BMI）

上一篇：2型糖尿病未合并冠心病患者B型脑钠肽与空腹血糖的相关性研究下一篇：上海地区2型糖尿病患者血清超氧化物歧化酶水平及其影响因素的分析

《中国糖尿病杂志》官方网站

编辑部在线

联系我们

女性2型糖尿病患者血尿酸水平与体质指数、血压和血脂关系的研究

相关阅读

热门推荐