2型糖尿病患者游离三碘甲状腺原氨酸与血脂代谢关系的研究

来自：中国糖尿病杂志编辑：杨宁王广徐援|点击数：|2016-03-04

【摘要】目的 评估不同血糖控制情况下T2DM患者甲状腺功能对血脂代谢的影响。方法选取住院T2DM患者595例，根据HbA₁c水平分为HbA₁c＜7.0%组108例、7.0%≤HbA₁c＜9.0%组164例及HbA₁c≥9.0%组323例，另选取健康体检者61名作为对照（NC）组。对各组指标进行比较，明确T2DM患者甲状腺功能指标与非高密度脂蛋白胆固醇(non-HDL-C)的关系。结果

HbA₁c≥9.0%组non-HDL-C水平高于HbA₁c＜7.0%组、7.0%≤HbA₁c＜9.0%组和NC组[（3.84±1.16）vs（3.32±1.07），3.59±0.96），（3.21±0.77） mmol/L，P均＜0.05]。HbA₁c≥9.0%组游离三碘甲状腺原氨酸(FT3)水平低于HbA₁c＜7.0%组、7.0%≤HbA₁c＜9.0%组和NC组[（2.43±0.50） vs （2.69±0.46），（2.66±0.45），（2.91±0.44） pg/ml，P均＜0.05]。T2DM患者non-HDL-C与BMI、FPG和HbA₁c呈正相关，与FT3呈负相关。多元线性回归分析提示，BMI、HbA₁c和FT3均是non-HDL-C的影响因素。结论随血糖升高，T2DM患者血脂代谢紊乱加重，FT3水平的下降，FT3是影响T2DM患者血脂变化的重要因素。

【关键词】糖尿病；2型；游离三碘甲状腺原氨酸；非高密度脂蛋白胆固醇

The study of relationship between serum free tri-iodothyronin and the lipid metabolism in patients with type 2 diabetes mellitus

【Abstract】 Objective To investigate the impact of thyroid function on lipid metabolism in type 2 diabetes mellitus (T2DM) patients stratified by blood glucose control. Methods A total of 595 T2DM patients were enrolled and divided into three groups according to HbA1c level： HbA₁c＜7.0% (n=108), 7.0%≤HbA₁c＜9.0% (n=164), HbA₁c≥9.0% (n=323). 61 healthy subjects were set as control (NC group). All subjects underwent assessment of thyroid function, glucose and lipid metabolism. Results HbA₁c≥9.0% group had higher levels of non-HDL-C and lower levels of free tri-iodothyronin (FT3) than HbA₁c＜7.0% group, 7.0%≤HbA₁c＜9.0% group and NC group [non-HDL-C:（3.84±1.16） vs （3.32±1.07）, （3.59±0.96）, （3.21±0.77）；FT3：（2.43±0.50）pg/ml vs （2.69±0.46）, （2.66±0.45）, （2.91±0.44）pg/ml, P＜0.05，respectively]. Non-HDL-C was positively correlated with BMI, FPG and HbA₁c, and negatively correlated with FT3 in T2DM patients. Multiple linear regression analysis showed that BMI, HbA₁c and FT3 were influence factors of non-HDL-C. Conclusions The disorder of lipid metabolism showed a deteriorating trend with the increase of blood glucose. FT3 was an influence factor of lipid metabolism in T2DM patients.

【Key Words】 Diabetes mellitus, Type 2; Free tri-iodothyronin; Non-high density lipoprotein cholesterol

上一篇：上海地区2型糖尿病患者血清超氧化物歧化酶水平及其影响因素的分析下一篇：Pax6基因的Arg67Arg与Thr166Thr突变致胰岛素分泌减少所致糖代谢异常与早发2型糖尿病的相关性研究

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2型糖尿病患者游离三碘甲状腺原氨酸与血脂代谢关系的研究

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