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2型糖尿病未合并冠心病患者B型脑钠肽与空腹血糖的相关性研究

来自:中国糖尿病杂志  编辑:何茜 谭洪文 于瑞萍等|点击数:|2016-03-04

 

    【摘要】 目的  探讨T2DM未合并冠心病患者血浆B型脑钠肽(BNP)FPG的相关性。 方法  选取经冠脉造影排除冠心病的T2DM患者175例,按照FPG水平分为FPG<7 mmol/L组、79 mmol/L组、>9 mmol/L组,检测各组BNPFPG等指标。  结果各组间BNP水平差异有统计学意义[(16.02±5.03) vs14.98±4.73vs14.12±4.65) pg/ml](P<0.01)。随着FPG水平的增高,BNP浓度降低。多元线性回归分析显示,BNP与年龄、SBPSUA呈正相关,与BMIFPGHbA1c呈负相关(P<0.05)Pearson相关分析显示,BNPFPG呈负相关(r= -0.775, P<0.01)  结论   BNP可能参与了血糖调节。

   【关键词】糖尿病,2型;冠心病;B型脑钠肽;空腹血糖

     The relationship between plasma brain natriuretic peptide and fasting plasma glucose in type 2 diabetic patients without coronary heart disease

   Abstract  Objective  To investigate the relationship between plasma brain natriuretic peptide(BNP) and FPG in type 2 diabetic patients without coronary heart disease. Methods  A total of 175 T2DM patients were selected. Coronary heart disease was ruled out by coronary angiograghy. All thepatients were divided into 3 groups according to their FPG levels: FPG<7mmol/L group (n=72), FPG 79 mmol/L group (n=58), and FPG>9 mmol/L group (n=45). BNP and FPG were measured in all groups. Results  The plasma BNP levelswere significantly diffe-rent among the three groups [(16.02±5.03),(14.98±4.73),(14.12±4.65 pg/ml)(P<0.01). The BNP level was decreased with the increasing of FPG. Multiple stepwise regression analysis showed that BNPwas positively 

correlated with age,SBP,and UA,but negatively correlated with BMI,FPG,and HbA1c (P<0.05). The Pearson correla-tion analysis showed that BNP was negatively correlated with FPGr= 0.775, P<0.01.  Conclusion  The plasma

BNP may participate in the regulation of blood glucose.

   【Key words】  Diabtetes mellitus,type 2Coronary heart disease(CHD)Brain natriuretic peptide(BNP)Fasting plasma glucose(FPG)

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