来自:中国糖尿病杂志 编辑:何茜 谭洪文 于瑞萍等|点击数:|2016-03-04
【摘要】 目的 探讨T2DM未合并冠心病患者血浆B型脑钠肽(BNP)与FPG的相关性。 方法 选取经冠脉造影排除冠心病的T2DM患者175例,按照FPG水平分为FPG<7 mmol/L组、7~9 mmol/L组、>9 mmol/L组,检测各组BNP、FPG等指标。 结果各组间BNP水平差异有统计学意义[(16.02±5.03) vs(14.98±4.73)vs(14.12±4.65) pg/ml](P<0.01)。随着FPG水平的增高,BNP浓度降低。多元线性回归分析显示,BNP与年龄、SBP、SUA呈正相关,与BMI、FPG、HbA1c呈负相关(P<0.05)。Pearson相关分析显示,BNP与FPG呈负相关(r= -0.775, P<0.01)。 结论 BNP可能参与了血糖调节。
【关键词】糖尿病,2型;冠心病;B型脑钠肽;空腹血糖
The relationship between plasma brain natriuretic peptide and fasting plasma glucose in type 2 diabetic patients without coronary heart disease
【Abstract】 Objective To investigate the relationship between plasma brain natriuretic peptide(BNP) and FPG in type 2 diabetic patients without coronary heart disease. Methods A total of 175 T2DM patients were selected. Coronary heart disease was ruled out by coronary angiograghy. All thepatients were divided into 3 groups according to their FPG levels: FPG<7mmol/L group (n=72), FPG 7~9 mmol/L group (n=58), and FPG>9 mmol/L group (n=45). BNP and FPG were measured in all groups. Results The plasma BNP levelswere significantly diffe-rent among the three groups [(16.02±5.03),(14.98±4.73),(14.12±4.65) pg/ml)(P<0.01). The BNP level was decreased with the increasing of FPG. Multiple stepwise regression analysis showed that BNPwas positively
correlated with age,SBP,and UA,but negatively correlated with BMI,FPG,and HbA1c (P<0.05). The Pearson correla-tion analysis showed that BNP was negatively correlated with FPG(r= 0.775, P<0.01). Conclusion The plasma
BNP may participate in the regulation of blood glucose.
【Key words】 Diabtetes mellitus,type 2;Coronary heart disease(CHD);Brain natriuretic peptide(BNP);Fasting plasma glucose(FPG)
版权所有:《中国糖尿病杂志》社 主管单位:中华人民共和国教育部 主办单位:北京大学
地址:北京市西城区大红罗厂街1号 邮编:100034 电话(传真):010-88505683
中国糖尿病杂志社版权所 京ICP备11029051号-1 Powered by JiuduCMS 技术支持:九度创想