【摘要】 T2DM患者存在严重的胰岛α细胞功能异常，包括空腹高胰升血糖素血症、胰岛α细胞对葡萄糖和IS降低及低血糖状态下胰岛α细胞代偿不良。胰升血糖素样肽-1（GLP-1）通过多种途径参与人体血糖调节，其中之一就是抑制胰岛α细胞分泌胰升血糖素。已有研究证实，以GLP-1为基础的肠促胰岛素类药物可通过直接或间接的途径抑制胰高血糖素分泌，改善T2DM患者的胰岛α细胞功能。

   【关键词】 胰岛α细胞；胰升血糖素；胰升血糖素样肽-1；肠促胰岛素类药物；糖尿病，2型

Effects of Incretinin pancreatic islet α-cell in patients with type 2 diabetes mellitus

   【Summary】 Dysfunction in pancreatic islet α-cellin patients with T2DMwas severe,including fastinghyperglucagone-miaand a decreasedsensitivity to glucose or insulin.Moreover,α cells cannot correspondingly increase glucagon secre-tionwhenhypoglycemia occurs.Glucagon-like peptide-1 (GLP-1) can regulate blood glucosethrough a variety of pathways, one of which issuppressingglucagon secretion.Previousstudies have demonstrated that GLP-1 basedincretin drugs can inhibit glucagon secretion and improve α-cell function directly or indirectly.

   【Key words】 Pancreatic islet α-cell；Glucagon；Glucagon-like peptide-1 (GLP-1)；Incretin；Diabetes mellitus，type 2