【摘要】  目的   探讨T2DM患者微量尿白蛋白（U-mAlb）、尿白蛋白/尿肌酐（UACR）与振动感觉阈值（VPT）及其影响因素的相关性。  方法   选取T2DM患者540例，根据UACR分为正常尿白蛋白(NAU)组、微量尿白蛋白（MAU)组和大量尿白蛋白（OAU)组。测定各组VPT、HbA1c等指标。  结果   MAU组和OAU组糖尿病病程、HbA1c和VP高于NAU组（P=0.000、0.008、0.000）。UACR与VPT、糖尿病病程、HbA1c呈正相关（P=0.002、0.003、0.004）。多元逐步回归分析显示，糖尿病病程和HbA1c是UACR的独立危险因素（P=0.015、0.011）。  结论   糖尿病病程是UACR的独立危险因素，随蛋白尿程度加重，VPT异常的发生率增加。
    【关键词】  糖尿病，2型；尿白蛋白/尿肌酐；振动觉阈值

     Relationship between albuminuria and vibration perception threshold in patients with type 2 diabetes mellitus

    【Abstract】  Objective   To investigate the relationship between urinary albumin creatinine ratio(UACR) and vibration perception threshold(VPT) in patients with type 2 diabetes mellitus (T2DM).  Methods   VPT, UACR, glycolated hemoglobin(HbA1c) were tested in 540 T2DM cases. They were assigned to normal albuminuria group (NAU), micro-albuminuria group(MAU) and overt-albuminuria group(OAU) according to the value of UACR. Results   Compared with NAU group, the duration of diabetes, HbA1c and VP is significantly higher in MAU group and OAU group（P=0.000, 0.008, 0.000）. VPT, diabetes duration and HbA1C were positively correlated with UACR（P=0.002, 0.003, 0.004）. Multiple stepwise regression analysis showed that diabetes duration (r=0.072, P=0.015) and HbA1c（r=0.054， P=0.011）are independent risk factors of UACR.  Conclusion  Diabetic duration is an independent risk factor of UACR. With the degree of proteinuria increased, the abnormality of VPT get worse.

    【Key  words】  Diabetes mellitus, type 2； Urinary albumin creatinine ratio（UACR）； Vibration perception threshold(VPT)