2型糖尿病患者合并低T3综合征与糖化血红蛋白和胰岛β细胞功能相关性的研究

来自：中国糖尿病杂志编辑：钟兴徐小群杜益君等|点击数：|2016-03-06

【摘要】目的探讨住院T2DM患者合并低T3综合征发生率、临床特点和相关危险因素。方法 249例T2DM患者根据甲状腺功能分为单纯T2DM（T2DM）组和T2DM合并低T3综合征（T2DM-LT3）组。检测HbA1c、FPG、FC-P、总三碘甲状腺原氨酸(TT3)、血清总甲状腺素(TT4)和促甲状腺激素（TSH）等指标。结果 T2DM-LT3组FC-P和HOMA-β低于T2DM组，糖尿病酮症发生率、HbA1c和FPG高于T2DM组（P＜0.05）。Pearson相关分析显示，TT3与HOMA-β和FCP呈正相关（r=0.192、0.174，P ＜0.01）；与HbA1c、FPG和糖尿病酮症呈负相关（r =－0.319、－0.222、－0.202，P＜0.01）。Logistic回归分析显示， FC-P、TG和HbA1c是低T3综合征的危险因素。结论 T2DM患者中低T3综合征可能与血糖控制不佳和胰岛功能受损相关。
【关键词】低T3综合征；糖尿病，2型；胰岛功能指数；糖化血红蛋白

Association analysis between low T₃ syndrome and HbA₁c, HOMA-β in patients with type 2 diabetes

【Abstract】 Objective To investigate the prevalence and clinical characteristics of low T₃ syndrome in hospitalized patients with type 2 diabetes. Methods A total of 249 type 2 diabetic patients were enrolled in this study and divided into two groups according to their thyroid function: T2DM with normal thyroid function (T2DM group) and T2DM with low T₃ syndrome (T2DM-LT₃ group). HbA₁c，FPG, FC-P, TT₃, TT₄ and TSH were measured in all subjects. Results FC-P and HOMA-β were significantly lower in T2DM-LT₃ group than in T2DM group. The prevalence of diabetic ketosis，HbA₁c and FPG were significantly higher in T2DM-LT₃ group than in T2DM group (P＜0.05).Pearson analysis showed that TT₃ was positively correlated with HOMA-β（r=0.192，P =0.000）and FCP（r=0.174，P=0.006）, and negatively correlated with HbA₁c (r=－0.319，P=0.000), FPG (r=－0.222，P=0.000), and incidence of diabetic ketosis (r=－0.202，P =0.001). Logistic regression analysis showed that FCP, TG, and HbA₁c were independent risk factors for low T₃ syndrome. Conclusion Low T₃syndrome may be associated with poor glycaemic control and damage of islet β cell in patients with type 2 diabetes.

【Key words】 Low T₃ syndrome; Diabetes mellitus, type 2; Islet β cell function; Hemoglobin (A₁c)

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2型糖尿病患者合并低T3综合征与糖化血红蛋白和胰岛β细胞功能相关性的研究

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