【摘要】  目的  探讨新疆维吾尔族T2DM患者Fosl2蛋白表达，及与IR和胰岛β细胞功能的关系。  方法   收集新疆喀什地区维吾尔族T2DM患者（T2DM组）及非糖尿病者（Non-DM组），各50例，测量身高、体重、WC、臀围、SBP、DBP，检测FPG、HbA1c、FIns、血脂及Fosl2蛋白水平，计算BMI、WHR、胰岛素抵抗指数（HOMA-IR)、胰岛β细胞功能指数（HOMA-β）及胰岛素敏感指数（HOMA-IS）。  结果 （1）T2DM组Fosl2蛋白水平[(18.09±19.48)vs（41.48±26.32） ng/ml]、HOMA-IS[(-4.93±

0.73）vs（-3.90±0.80）]及HOMA-β[（3.63±0.97）vs（4.65±0.85）]低于Non-DM组（P＜0.01），而BMI、FPG、HbA1c、TC、TG、LDL-C、HDL-C、FIns及HOMA-IR均高于Non-DM组（P＜0.05）；（2）相关性分析显示，在维吾尔族人群中，Fosl2水平与BMI、FPG、HbA1c、TC、HOMA-IR呈负相关(P＜0.05），与HOMA-IS呈正相关(P＜0.01）；在维吾尔族T2DM组中，Fosl2水平与TG呈正相关，与FIns、HOMA-β呈负相关（r=0.536、-0.465、-0.469，P＜0.05）。  结论  Fosl2蛋白表达水平与新疆维吾尔族IR、胰岛β细胞功能密切相关，Fosl2蛋白表达水平下调可能参与了维吾尔族T2DM的发生发展。

   【关键词】  新疆维吾尔族；Fosl2基因；糖尿病，2型；胰岛素抵抗；胰岛β细胞功能。

   【Abstract】  Objective   To detect the relationship between Fosl2 protein expression and insulin resistance and β-cell function in patient with type 2 diabetes（T2DM） in Xinjiang Uygurs.  Methods   50 cases with T2DM (T2DM group) and 50 non-diabetic controls (Non-DM group) were recruited in Uygurs. All the subjects accepted physical examinations including height, weight, waist circumference, hip circumference， SBP, and DBP. The levels of FPG, HbA₁c, FIns, and lipids and the expression of Fosl2 protein were detected. The indicators of BMI, WHR, Insulin resistance index (HOMA-IR), insulin-β cell function index (HOMA-β) and insulin sensitivity index (HOMA-IS) were calculated.  Results  （1）The expression of Fosl2 protein in T2DM group (41.48 ± 26.32) ng/mL was significantly lower than in Non-DM group (41.48 ± 26.32）ng/mL. Compared with Non-T2DM group, lnHOMA-IS and lnHOMA-β were significantly lower in T2DM group in Xinjiang Uygurs(P＜0.01）, while BMI, FPG, HbA₁c, TC, TG, LDL-C, HDL-C, FIns and HOMA-IR levels were higher（P＜0.01）. （2） Pearson correla-tion analysis showed that the expression of Fosl2 protein negatively correlated with BMI, FPG, HbA₁c,TC and HOMA-IR(P＜0.05), and positively correlated with HOMA-IS in Uygur(P＜0.01). The expression of Fosl2 protein had positive correlation with TG, and negative correlation with FIns, HOMA-β（r=-0.465，-0.469，P＜0.05) in T2DM group in Xinjiang Uygurs.  Conclusion  The expression of Fosl2 protein was related with insulin resistance and β-cell function of Uygurs. The down regulation of Fosl2 protein expression may involved in the development of T2DM in Xinjiang Uygurs.

【Key words】 Xinjiang Uygur; Fosl2 gene ;Type 2 Diabetes ;insulin resistance; pancreatic β-cell function