【摘要】  目的   探讨早期糖尿病慢性肾脏疾病（CKD）患者血清分泌型卷曲相关蛋白5 (SFRP5)与早期糖尿病肾病（EDN）的相关性。  方法   选择新诊断单纯 T2DM 患者43 例、EDN患者42例，另选择健康体检者（NC ) 42名。 ELISA测定空腹血清SFRP5水平。  结果  3组血清SFRP5水平依次为: NC组（5.02±0.69）μg/L vs T2DM组（4.37±0.53）μg/L vs  EDN组（3.76±0.49）μg/L（P＜0.05或P＜0.01）。血清SFRP5水平与胰岛素抵抗指数（HOMA-IR）、FIns、FPG、HbA1c、BMI、IL-6、TG、TNF-α、UAER、尿白蛋白/肌酐（UAlb/Cr）、病程呈负相关（r=-0.573、-0.522、-0.589、-0.601、-0.467、-0.515、-0.542、-0.647、-0.592、-0.638、-0.553，P＜0.05或P＜0.01）,与SOD呈正相关（r=0.603， P＜0.01）。多元逐步回归分析显示，HOMA-IR、TNF-α、UAlb/Cr是SFRP5的独立影响因素。  结论   EDN患者血清SFRP5水平降低，血清SFRP5 与EDN 的严重程度相关。

   【关键词】 分泌型卷曲相关蛋白5；糖尿病，2型；糖尿病肾病 

  【Abstract】  Objective  To explore the association between serum secreted frizzled-related protein 5(SFRP5) and early type 2 diabetic nephropathy(EDN).  Methods  A total of 127 subjects were enrolled in this study and divided into three groups: patients with newly diagnosed type 2 diabetes（T2DM group, n=43）， patients with early diabetic nephropathy（EDN group, n=42）,and healthy subjects with normal glucose tolerance（NC group, n=42）.Serum SFRP5 was measured by ELISA.  Results   The serum SFRP5 were(5.02±0.69)μg/L, (4.37±0.53)μg/L, and (3.76±0.49)μg/L in NC, T2DM and EDN group respectively  (P＜0.05 or P＜0.01). (2) SFRP5 were negatively correlated with HOMA-IR，FIns, FPG，HbA₁c, BMI, IL-6, TG,TNF-α,UAER,UAlb/Cr, and duration of diabetes（r=-0.573,-0.522,-0.589,-0.601,-0.467,-0.515,-0.542,-0.647,-0.592,-0.638,-0.553， P＜0.05 or P＜0.01)，and positively correlated with SOD（r=0.603，P＜0.01). Multiple linear regression analysis showed that HOMA-IR, TNF-α and UAlb/Cr were independent influencing factors for SFRP5.  Conclusion  Serum SFRP5 is decreased in patients with EDN. Serum SFRP5 is associated with severity of DN.

  【Key words】  Secreted frizzled-related protein 5(SFRP5)；Diabetes mellitus，type 2；Diabetic nephropathy(DN)