来自:中国糖尿病杂志 编辑:张梅 胡大春 张鸿青等|点击数:|2016-03-04
【摘要】 目的 探讨H型高血压对T2DM患者肾脏损伤的作用。 方法 选择尿常规检查尿蛋白阴性T2DM患者528例,分为单纯T2DM组、T2DM伴高血压组、T2DM伴高同型半胱氨酸(Hcy)组和T2DM伴H型高血压组。观察各组尿白蛋白/肌酐比值(UAlb/Cr)、eGFR、血肌酐(Scr)、胱抑素C(Cys-C)等指标。 结果 单纯T2DM组、T2DM伴高血压组、T2DM伴H-Hcy组和T2DM伴H型高血压组UAlb/Cr水平分别为8.00、10.09、11.48和14.06 mg/24 h;eGFR为(94.28±18.01)(84.86±18.74)、(85.90±18.09)和(75.64±19.43)ml/(min·1.73)m2;Scr为(76.16±17.64)、(78.73±14.75)、(84.74±17.17)和(97.35±64.17) μmol/L;Cys-C为(0.93±0.26)、(0.98±0.17)、(1.10±0.29)和(1.16±0.33)mg/L。Logistic分析显示,Hcy是UAlb/Cr和eGFR的危险因素。 结论 H型高血压增加了T2DM患者的肾脏损伤。
【关键词】 糖尿病,2型;同型半胱氨酸;肾损伤
【Abstract】 Objective To investigate the renal damagein type 2 diabetic patients with high level of ho-mocysteineassociated hypertension. Methods A total of 528 type 2 diabetic patients with negative urinary protein by routine examination were recruited in this study. All the subjects were divided into four group saccording to their blood pressure and homocysteine: T2DM group, T2DM+hypertension group, T2DM+high level of homocysteine group, and T2DM+hypertension+high level of homocysteine group. UACR, eGFR,Scr and Cys-C were measured in all the participants. Results The levels of UACR were 8.00, 10.09, 11.48,14.06; eGFR were;
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