血清趋化素与2型糖尿病患者骨密度水平的相关性研究

来自：中国糖尿病杂志编辑：施良张浩李林等|点击数：|2016-03-04

【摘要】 目的探讨血清趋化素（chemerin）水平与T2DM患者骨密度及相关因素的关系。方法选取T2DM患者167例，根据WHO骨质疏松诊断标准分为糖尿病骨量正常组、糖尿病骨量减少组和糖尿病骨质疏松组，另选取健康对照（NC）组36名，测量并记录患者临床一般资料及生化指标，检测血清chemerin、IL-6及TNF-α水平。结果糖尿病骨质疏松组血清chemerin水平高于糖尿病骨量正常组[（89.6±12.1） vs （64.7±13.6）ng/mL，P＜0.05]。糖尿病骨质疏松症组血清炎症因子TNF-α和IL-6水平高于糖尿病骨量正常组(P＜0.05)。血清chemerin水平与病程、HbA₁c、BMI、TNF-α呈正相关（r=0.31、0.35、0.76、0.45，P＜0.05），与腰椎骨密度呈负相关（r=-0.46，P＜0.05）。多元线性回归分析显示，chemerin是T2DM患者腰椎骨密度的独立影响因素。结论炎症是糖尿病骨质疏松的重要病理生理过程，chemerin可能通过调控炎症反应参与骨代谢过程，从而促进骨质疏松的发生。

【关键词】 糖尿病，2型；趋化素；骨质疏松症；骨密度

Correlation study of serum chemerin level and bone mineral density in T2DM patients

【Abstract】 Objective To explore the relationship between serum chemerin level and bone mineral density (BMD) in T2DM patients. Methods A total of 167 patients with T2DM were enrolled and divided into three groups according to WHO criteria of osteoporosis： bone mass normal group, bone mass reduction group and osteoporosis (OP) group. 36 healthy subjects were set as control group. Clinical data and related biochemical parameters were recorded. The levels of serum chemerin， IL-6，and TNF-α were tested. Results The patients in three groups with T2DM had no significant difference in age, sex, height, weight, duration of diabetes and HbA₁c. Compared with type 2 diabetic bone mass normal group, the chemerin levels increased significantly in OP group [（89.6±12.1）vs（64.7±13.6） ng/ml, P＜0.05]. TNF-α levels were significantly higher in OP group than that in type 2 diabetic bone mass normal group (P＜0.05). Correlation analysis showed that serum chemerin were positively correlated with duration of diabetes, HbA₁c, BMI, and TNF-α（r=0.31, 0.35, 0.76, 0.45, P＜0.05）Paand negatively correlated with BMD (L1-4)（r=-0.46, P＜0.05）and TNF-α were independent influencing factors for diabetic osteoporosis. Conclusion and TNF-α were independent influencing factors for diabetic osteopo-rosis. Conclusion Inflammation is an important pathophysiological process of diabetic osteoporosis. Chemerin may play roles in the pathogenesis of diabetic osteoporosis by regulating inflammatory reaction.

【Key words】 Diabetes mellitus，type 2; Chemerin; Osteoporosis; Bone mineral density( BMD)

上一篇：糖尿病伴牙周炎患者全唾液中牙周致病菌的检测及其临床意义下一篇：2型糖尿病伴H型高血压对肾脏损伤的临床观察

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