【提要】 分泌型卷曲相关蛋白5（SFRP5）是新发现的脂肪因子，可通过抗炎机制改善IR。对肥胖和T2DM患者进行药物或生活方式干预可提高血循环SFRP5水平，改善IS。 SFRP5或可成为肥胖和T2DM新的治疗靶点。

【关键词】 分泌型卷曲相关蛋白5；脂肪因子；胰岛素抵抗；代谢性疾病

The progression of the research on SFRP5 and obesity and related metabolic diseases      ZHU Yun-xia, ZHONG Yuan, Department of Geriatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

Corresponding author: ZHONG Yuan, E-mail：zhyy_666@163.com

【Summary】 Secreted frizzled-related protein 5 is a novel adipokine, which has been shown to improve insulin resistance by inhibiting inflammation. Anti-diabetes drugs and lifestyle interventions have been reported to improve insulin resistance and increase circulating SFRP5 level in subjects with type 2 diabetes (T2DM) and obesity. SFRP5 may become the new therapeutic target.

【Key words】Secreted frizzled-related protein 5; Adipokine; Insulin resistance; Metabolic diseases