来自:中国糖尿病杂志 编辑:杨东明 陆志芳 何华伟|点击数:|2015-04-09
糖尿病临床研究
【摘要】 目的 观察天麦消渴片与二甲双胍缓释片联合门冬胰岛素30治疗新诊断老年T2DM患者的疗效。 方法 将新诊断老年T2DM患者83例分为对照组41例和治疗组42例,对照组予口服二甲双胍缓释片联合门冬胰岛素30治疗,治疗组在对照组基础上加用天麦消渴片,疗程12周,观察两组治疗前后各项指标。 结果 治疗组治疗后SBP、FPG、2 hPG、HbA1c、TG、TC、胰岛素用量和血糖达标时间较对照组低[(138.0±11.0) vs (143.0±9.0)mmHg;(6.4±0.9) vs (8.0±1.2)mmol/L;(6.6±1.0) vs (8.3±1.2)mmol/L;(6.4±0.5)% vs (7.5±0.6)%;(3.10±1.10) vs (3.04±1.03)mmol/L;(6.04±1.13) vs (6.15±1.32)mmol/L;(22.0±2.0) vs (26.0±4.0)U;(8.5±2.0) vs (10.0±1.8)d,P<0.05],其余指标比较差异均无统计学意义(P>0.05)。两组均无严重低血糖事件发生。 结论 天麦消渴片与二甲双胍缓释片联合门冬胰岛素30治疗可有效降低新诊断老年T2DM患者SBP、FPG、2 hPG、HbA1c、TG和TC水平,且胰岛素用量少,血糖达标时间短,无严重低血糖事件发生。
【关键词】天麦消渴片;二甲双胍缓释片;门冬胰岛素30;糖尿病,2型
【Abstract】 Objective To observe the therapeutic effect of extended-release metformin plus insulin aspart30 injection with versus without Tianmaixiaoke tablets in elderly patients with newly diagnosed T2DM. Methods 83 elderly patients with newly diagnosed T2DM were divided into two groups, control group was treated with oral extended-release metformin and insulin aspart30 injection, and treatment group were treated with Tianmaixiaoke tablets added on the treatments of control group. The changes of each index were observed before and after treatment. Results SBP, FPG, 2 hPG, HbA1c, TG, TC, insulin dose and glucose target arrival time were significantly lower in treatment group than in control group [(138.00±11.00) vs (143.00±9.00)mmHg; (6.40±0.90) vs (8.00±1.20)mmol/L; (6.60±1.00) vs (8.30±1.20)mmol/L; (6.40±0.50)% vs (7.50±0.60)%; (3.10±1.10) vs (3.04±1.03)mmol/L; (6.04±1.13) vs (6.15±1.32)mmol/L; (22.00±2.00) vs (26.00±4.00)U; (8.50±2.00) vs (10.00±1.80)d, P<0.05]. There were no statistically significant difference in BMI, SBP, DBP, TG, TC, HDL-C and LDL-C between two groups (P>0.05). No severe hypoglycemia event occurred in two groups. Conclusion The treatment with Tianmaixiaoke tablets, extended-release metformin and insulin aspart30 injectionin elderly patients with newly diagnosed T2DM could effectively reduce the levels of SBP, FPG, 2 hPG, HbA1c, TG , TC, therapy dosage of insulin and glucose target arrival time. No severe hypoglycemic eventsoccur in treatment group.
【Key words】 Tianmaixiaoke tablets;Extended-release metformin;Insulin aspart30;Mellitus diabetes,type 2
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