糖尿病临床研究

　　【摘要】 目的 探讨T2DM患者血尿酸(SUA)水平与经皮氧分压(TcPO2)的相关性。 方法 选取T2DM住院患者622例，根据SUA水平将研究对象分为高尿酸血症(HUA)组和正常SUA(T2DM)组，比较两组TcPO2初始值、稳定值、稳定值与初始值的差值、抬腿初始值、抬腿最大值的差异，分析SUA与TcPO2各参数的相关性。 结果 HUA组左、右侧TcPO2初始值、稳定值低于T2DM组[初始值：左(34.05±13.17) vs (39.26±15.82)，右(34.71±14.90) vs (40.15±16.23);稳定值：左(38.93±12.23) vs (45.19±13.40)，右(39.98±12.34) vs (45.90±16.77)，P<0.05]。Pearson相关性分析结果显示，SUA水平与左、右侧TcPO2稳定值呈负相关，SUA水平与左、右侧TcPO2稳定值和初始值的差值呈负相关(P<0.05或P<0.01)。多元线性回归分析结果显示，SUA水平是左侧TcPO2稳定值的影响因素。 结论 T2DM患者SUA水平与TcPO2相关，提示HUA可能是微循环障碍的影响因素。

　　【关键词】糖尿病，2型;高尿酸血症;微循环障碍

　　【Abstract】Objective To explorethe relationship between serum uric acid (SUA) andtranscutaneous oxygen pressure (TcPO2) in patients with type 2 diabetes (T2DM). Methods 622 hospitalized patients with T2DM were recruited and divided into high SUA (HUA)group and normal SUA (T2DM)group. The differences inTcPO2(initial value, stable value, initial value-stable value, leg-raisinginitial value and leg-raisingmaximum value)were compared between two groups.The correlations between SUA and TcPO2 were evaluated. Results The levels of TcPO2 were lower in HUA group than in T2DM group [initial value: left (34.05±13.17) vs (39.26±15.82), right (34.71±14.90) vs (40.15±16.23); stable value: left (38.93±12.23) vs(45.19±13.40), right (39.98±12.34) vs (45.90±16.77), P<0.05]. Pearson correlation analysis showed that the SUA levels negatively related with the stable TcPO2value of leftor right side , and with the change between the initial value and the stable value of TcPO2(P<0.05 or P<0.01). The multiple linear regression analysis showed that SUA level was the impact factorof the left TcPO2 stable value. Conclusion HUA may be one of the risk factors microcirculation disorder in T2DM patients.

　　【Key words】Diabetes mellitus，type 2;High serum uric acid disease(HUA);Microcirculation disorder