·糖尿病临床研究·

  　【摘要】 目的 观察新诊断T2DM患者血清中25羟维生素D[25(OH)D]与胰岛β细胞第一时相分泌的关系。 方法 选取新诊断T2DM患者(T2DM组)188例及正常对照(NGT组)组190名，测定临床资料和生化指标。以葡萄糖刺激后3～5 min急性胰岛素反应(AIR3-5)表示第一时相胰岛素分泌功能指数，并进行比较分析。 结果 T2DM组25(OH)D和AIR3-5均低于NGT组[25(OH)D:(14.7±9.4) vs (36.7±11.3);AIR3-5：(7.58±2.25 vs 57.38±9.34)，P<0.05];AIR3-5与25(OH)D和HDL-C呈正相关(P<0.05),与TC、TG、LDL-C、BMI、WHR、FFA、2 hFFA、FPG、2 hPG、FIns均呈负相关(P均<0.05)。25(OH)D、TG和BMI是AIR3-5的独立影响因素(β=0.351、-0.328、-0.238，P均<0.05)。 结论 新诊断T2DM患者25(OH)D和AIR3-5水平均降低，且呈正相关，25(OH)D可预测胰岛素分泌功能。

　　【关键词】 糖尿病，2型;25羟维生素D;急性胰岛素反应

　　【Abstract】 Objective To evaluate the relationship between serum25-hydroxy vitamin D [25(OH)D] and the first-phase insulin secretion of beta cell in newly diagnosed type 2 diabetic patients. Methods Clinical characteristics and laboratory data were collected in 188 newly diagnosed type 2 diabetic patients (T2DM group) and 190 normal glucose tolerance subjects (NGT group). AIR3-5(3～5 minutes acute insulin response) was calculated as the average internal insulin concentration during 3 to 5 minutes after the glucose loading and the results were compared between two groups. Results The levels of serum 25(OH)D and AIR3-5 were lower in T2DM group than in NGT group[25(OH)D:(14.7±9.4)vs(36.7±11.3);AIR3-5：(7.58±2.25 vs 57.38±9.34)，P<0.05]. AIR3-5 was positively associated with 25(OH)D and HDL-C(P<0.05), and negatively correlated with TC, TG, LDL-C, BMI, WHR, FFA, 2 hFFA, FPG, 2 hPG and FIns(all P<0.05).The 25(OH)D, TG and BMI were the independent relative factors for AIR3-5. ConclusionsThe levels of 25(OH)D and AIR 3-5 are decreased in newly diagnosed type 2 diabetes mellitus. AIR3-5 is positively correlated with 25(OH)D, and 25(OH)D may predict insulin secretion capability .

　　【Key words】 Diabetes mellitus， type 2;25-hydroxy vitamin D[25(OH)D];Acute insulin response