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2型糖尿病患者促甲状腺激素水平与胰岛素抵抗指数的相关性研究

来自:中国糖尿病杂志  编辑:朱平 刘新亮 李鞠 张瑜 吴红艳 莫先阳|点击数:|2015-04-29

  糖尿病伴发症

  【摘要】 目的 探讨T2DM患者促甲状腺激素水平(TSH)与IR的关系。 方法 选取213例T2DM(T2DM)患者及正常对照(NC)者107名。以HbA1c7%为切点再将T2DM组分为高HbA1c亚组和低HbA1c亚组,分析TSH与IR的相关性。 结果 相关分析结果显示,TSH与HOMA-IR呈正相关(r=0.302、0.495,P<0.05)。亚组分析结果显示,两亚组TSH与HOMA-IR呈正相关(r=0.311、0.584,P<0.05)。多元回归分析显示,TSH和BMI是IR的独立危险因素。 结论 T2DM患者TSH水平与HOMA-IR呈正相关。

  【关键词】促甲状腺激素;胰岛素抵抗;糖尿病,2型

  【Abstract】 Objective To assess the relationship between thyroid stimulating hormone (TSH) levels and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM). Methods 213 cases of T2DM and 107 normal controls (NC) were collected for this retrospective study. Based on HbA1c cut-off of 7%, diabetic patients were divided into two subgroups: HbA1c≥7%, and HbA1c<7%. Linear regression analyses were used to evaluate the association of TSH and HOMA-IR. Results Linear regression analysis showed that TSH levels were positively associated with HOMA-IR both in T2DM and NC groups (r=0.302, P=0.002; and r=0.495, P<0.001, respectively). Subgroup analyses revealed the same linear relationship in HbA1c≥7% subgroup (r=0.584, P<0.001) and HbA1c<7% subgroup (r=0.311, P=0.038). Conclusion TSH levels within reference range were linearly and positively associated with HOMA-IR in type 2 diabetic patients and non-diabetic subjects, especially in patients with poor glucose control (HbA1c≥7%).

  【Key words】 Thyroid stimulating hormone; Insulin resistance; Diabetes mellitus, type 2

上一篇:2型糖尿病合并大血管病变患者血清松弛素和基质金属蛋白酶-2表达水平及其相关性研究 下一篇:2型糖尿病合并非酒精性脂肪性肝病血糖波动与非酒精性脂肪性肝病肝纤维化评分的相关性分析

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