·糖尿病流行病学调查·

　　【摘要】 目的 分析全血中NF-κB蛋白表达水平与MS的相关性。 方法 选取MS患者(MS组)120例及同地区健康农村居民(NC组)120名，采用t检验、偏相关分析、条件Logistic回归等方法，分析NF-κB与MS的相关性。 结果 MS组全血中NF-κB蛋白水平低于NC组[(352.31±307.35) vs (441.00±345.10) ng/L，P<0.05];MS组男性、汉族、45～55岁者NF-κB蛋白水平均低于NC组(P<0.05)。偏相关分析显示，全血NF-κB蛋白水平与BMI存在相关性(β=-0.1459，P=0.025)。条件Logistic回归分析显示，全血NF-κB蛋白是MS发生的保护因素(OR=0.91，95%CI：0.72～0.98，P<0.05)。 结论 全血中NF-κB蛋白水平与MS存在一定的相关性。

　　【关键词】 核转录因子κB;代谢综合征

　　【Abstract】 Objective To investigate the correlation of NF-κB with Metabolic Syndrome(MS). Methods A total of 240 subjects living in rural areas of Ningxia were enrolled in this study and divided into two groups: MS group(n=120) and healthy control group(n=120). The relationship of NF-κB with MS was evaluated by t-test, partial correlation and conditional logistic regression analysis. Results Whole blood NF-κB protein level was significantly lower in MS group than in control group [(352.31±307.35 ) vs (441.00 ±345.10) ng/L, P<0.05]. Whole blood NF-κB protein level was significantly lower in male, Han nationality, and 45～55 years old patients of MS group than in control group (P<0.05). Partial correlation analysis showed that NF-κB was associated with BMI(β=-0.1459, P=0.025). Conditional logistic regression analysis showed that whole blood NF-κB protein was a protective factor for MS (OR=0.91, 95%CI:0.72～0.98, P<0.05). Conclusion The blood NF-κB level is associated with metabolic syndrome.

　　【Key words】 NF-κB; Metabolic syndrome; Correlation