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2型糖尿病合并非酒精性脂肪性肝病血糖波动与非酒精性脂肪性肝病肝纤维化评分的相关性分析

来自:中国糖尿病杂志  编辑:郭亚楠 李明珍 孙丽荣 耿思思 张甜|点击数:|2015-04-29

  糖尿病伴发症

  2型糖尿病合并非酒精性脂肪性肝病患者血糖波动与非酒精性脂肪性肝病肝纤维化评分的相关性分析

  郭亚楠李明珍 孙丽荣 耿思思 张甜

  【摘要】 目的 探讨T2DM合并非酒精性脂肪性肝病(NAFLD)患者血糖波动与非酒精性脂肪性肝病肝纤维化评分(NAFLDFS)的相关性。 方法 根据NAFLDFS将107例T2DM合并NAFLD患者分为肝纤维化低危组(NAFLDFS<0.676)和肝纤维化组 (NAFLDFS≥0.676),比较两组间血糖波动等指标,并行Logistic回归分析。 结果 两组病程、BMI、WC、WHR、HbA1c、HDL-C及平均血糖波动幅度(MAGE)比较差异均有统计学意义(P<0.05或P<0.01)。Logistic回归分析发现,MAGE是NAFLDFS的独立危险因素(OR=2.108 95%CI:1.088~4.085)。结论 T2DM合并NAFLD患者MAGE与NAFLDFS独立相关。

  【关键词】糖尿病,2型;非酒精性脂肪性肝病;血糖波动;非酒精性脂肪性肝病肝纤维化评分

  【Abstract】 Objective To investigate the association between glucose variability and nonalcoholic fatty liver disease fibrosis score (NAFLDFS) in type 2 diabetes mellitus(T2DM) patients with nonalcoholic fatty liver disease(NAFLD). Methods According to the scores of NAFLDFS, a total of 107 subjects were divided into two groups: with low risk of liver fibrosis (NAFLDFS<0.676),with liver fibrosis (NAFLDFS≥0.676).Glucose variability and related indices were compared. Logistic regression analysis was used to examine the risk factors for liver fibrosis. Results There were significant differences in the course of disease,body mass index (BMI),waist circumference (WC),waist-hip ratio (WHR),human glycated hemoglobin A1c (HbA1c), high density lipoprotein cholesterol(HDL-C), and mean amplitude of glycemic excursions(MAGE) between the two groups( P<0.05 or P<0.01). Logistic regression analysis showed that MAGE was the independent risk factor for NAFLDFS (OR=2.108, 95%CI 1.088~4.085). Conclusion Glucose variability is significantly related to NAFLDFS in T2DM patients with NAFLD.

  【Key words】 Diabetes mellitus, type 2;Nonalcoholic fatty liver disease;

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