来自:中国糖尿病杂志 编辑:袁平宗 胡江红 汤雪彪 甘华葵|点击数:|2015-04-29
糖尿病临床流行病学
[摘要] 目的 了解四川省内江市20~60岁企事业单位工作人员的糖代谢状态。 方法 对四川内江地区20~60岁企事业单位工作人员整体分层随机抽取9905名,行FPG检测。FPG≥5.6 mmol/L者再检测2 hPG。 结果 共检出血糖异常(FPG≥6.1 mmo/L)1296例(13.1%);IFG 1095例(11.1%)。不同性别、年龄比较差异有统计学意义。随年龄增长,血糖异常逐渐增加,50~60岁组血糖异常达18.5%。2 hPG检测结果显示,随FPG升高,IGT和糖尿病检出率逐渐增高。 结论 四川省内江市糖尿病及糖尿病前期患病率较高,尽早发现糖尿病前期人群,有利于尽早干预,以减少糖尿病的发生。
[关键词] 糖代谢;口服糖耐量试验;空腹血糖;空腹血糖受损
【Abstract】Objective To evaluate the effect of age on the performance of hemoglobin(HbA1c) and glycated albumin(GA)for detecting undiagnosed diabetes in Chinese populations. Methods Twostudy populations came from communities and hospitals, respectively. A total of 876 volunteers aged ≥20 years without known diabetes living in two communities in Beijing were recruited. Data of 9592 individuals without known diabetes from 37 hospitals in China were collected. 75g glucose tolerance tests (OGTT) were performed, and HbA1c and GA were measured. Individuals were divided into groups based on age tertiles. Receiver operating characteristic curves (ROCs) were plotted and the areas under the curves (AUCs) for HbA1c and GA values were compared among three age groups. Results The ROC AUC of HbA1c for detecting diabetes in the 21~50, 51~57 and 58~79 years age group in the community population was 0.977, 0.934 and 0.865 (P < 0.005), respectively. the ROC AUC of GA for detecting diabetes was 0.903,0.854 and 0.845 (P =0.591), respectively. The ROC AUC of HbA1c for detecting diabetes in the 18~47, 48~59 and 60~75 years age group in the hospital population was 0.936,0.889 and 0.849(P<0.05), respectively. Conclusions The accuracy of HbA1c for detecting undiagnosed diabetes decreases with increasing age. The impact of age on GA for detecting diabetes needs further investigation.
【Key words】Diabetes mullitus;Hemoglobin (A1c);Glycatedalbumin(GA);Screening;Age
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