【摘要】 目的探讨MS合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床特点及预测发病的相关因素，并观察持续气道正压通气(CPAP)治疗对MS的影响。 方法    将研究对象分为MS组44例、MS合并OSAHS组112例、无中心性肥胖OSAHS组46例及正常对照(NC)组63名，分析其临床参数；对42例合并OSAHS的MS患者给予CPAP治疗后观察临床参数的变化。 结果   MS患者中，OSAHS发病率为71.79％(112/156)，MS患者与OSAHS发病相关的各指标依次为Epworth嗜睡表(ESS)评分、颈围(NC)、醒后SBP和DBP(OR＝5.615、3.257、3.142、2.881)；合并OSAHS的MS患者经CPAP治疗后，ESS、血压、各代谢指标、体重等分别于2周、4周和8周得到了改善(P<0.05)。 结论    MS患者存在着较高的OSAHS并存率，MS患者的ESS、NC和醒后血压与OSAHS的发生有较好的相关性，对OSAHS进行治疗后可改善MS病情。
     【关键词】代谢综合征；阻塞性睡眠呼吸暂停低通气综合征；持续气道正压通气
 

   【Abstract】 Objective   To study the clinical features and predictors of obstructive sleep apnea hypopnea syndrome(OSAHS)in metabolic syndrome(MS)patients，and to investigate the effect of continuous positive airway pressure(CPAP)treatment． Methods   Patients with MS and/or OSAHS were recruited and assigned into four groups：MS group(n＝44)。MS+OSAHS group(n=112).OSAHS group(n＝46)without central obesity. 63 healthy people were select as normal control (NC group).Clinical data were collected and compared among these four groups。and in 42 cases of MS+OSAHS before and after CPAP treatment． Results   The incidence of OSAHS was 71.79％(112/156)in MS group．Multivariate logistic regression analysis showed that ESS scores,neck collar (NC)，and the blood pressure after waking were significantly correlated with the occurrence of OSAHS in MS patients(OR＝5.615，3.257，3.142，2.881)．After 2,4 and 8 weeks of CPAP treatment，it was observed there were significant

decreases in ESS scores，blood pressure, FPG and weight. Conclusion   MS and OSAHS had a high rate of coexist．ESS，NC and the blood pressure after waking can predict the risk of OSAHS．CPAP treatment was beneficial for MS．

  【Key words】 Metabolic syndrome(MS)；Obstructive sleep apnea hypopnea syndrome (OSAHS)；

Continuous positive airway pressure(CPAP)