糖尿病大血管病变

　　　【摘要】 目的 比较年龄<40岁与≥40岁新诊断T2DM患者心血管病变(CVD)危险因素水平及聚集情况。 方法 选取既往无冠心病(CHD)病史的新诊断T2DM患者568例，分为年龄<40岁组136例和年龄≥40岁组432例，收集一般资料和主要病史等，检测血糖、血脂、HbA1c、高敏C反应蛋白(hsC-RP)和24 hUAlb等指标。 结果 年龄<40岁组BMI、BP、血糖、血脂、HbA1c、hsC-RP、UAlb、吸烟、CVD家族史、肥胖/超重、BP升高、血脂异常、蛋白尿阳性率以及合并不同CVD危险因素数量的发生率与年龄≥40岁组比较差异无统计学意义，但血脂异常、BP升高的病情知晓率及治疗率低于年龄≥40岁组(P<0.01)。 结论 年龄<40岁与≥40岁新诊断T2DM患者具有相似CVD风险，但前者病情知晓率及治疗率更低。

　　【关键词】糖尿病，2型;心血管病变;危险因素;年龄

　　【Abstract】 Objective To investigate the differences of the levels and accumulations of cardiovascular disease (CVD) risk factors between the newly-diagnosed T2DM patients aged<40 years and≥40 years. Methods 568 newly-diagnosed T2DM patients without coronary heart disease (CHD) history were recruited, and divided into aged<40 years group (n=136) and ≥40 years group (n=432). General information and main medical history were collected. Blood glucose, blood lipid, HbA1c, high-sensitive C reactive protein (hsC-RP) and 24 hUAlb were detected. Results There were no significant differences in the incidence of smoking, CVD family history, overweight/obesity, hypertension, dyslipidemia, proteinuria and the levels of BMI, blood pressure, blood glucose, blood lipid, HbA1c, hsC-RP, UAlb between two groups. The accumulation of CVD risk factors was similar between two groups. The awareness and therapy rates of hypertension and dyslipidemia were significantly lower in aged<40 years group than in aged≥40 years (P<0.01). Conclusion The newly-diagnosed T2DM patients aged<40 years and≥40 years are exposed to similar CVD risk level, while the awareness and therapy rates of such conditions are lower in the former group.

　　【Key words】Diabetes mellitus, type 2;Cardiovascular disease (CVD);Risk factors;Age