药物研究动态

　　【提要】无论是否已诊断为糖尿病，患者在住院期间出现的高血糖都应该得到充分重视和有效管理。以高血糖为主的代谢异常使手术中发生危险及术后伤口不愈合、感染等发生率都大大增加。严格控制住院患者的高血糖是保障手术成功及减少术后并发症的关键。理想的胰岛素治疗方案应是个体化的，兼顾良好的血糖控制并减少低血糖发生风险。基础-餐时胰岛素治疗方案更符合生理性胰岛素需求，能够安全平稳降糖，有利于改善住院患者的预后。

　　【关键词】住院高血糖;基础-餐时方案;门冬胰岛素;地特胰岛素

　　【Summary】Inpatient hyperglycemia should be paid enough attention, no matter related to diagnosed diabetes or not. Metabolic disorder characterized by hyperglycemia increases incidence of surgical risk, poor wound healing, and causes much higher risk of infections than that in hospitalised patients with normal glycemia. Therefore, sufficient inpatient blood glucose control is important to a successful surgery and less complications after surgery. An ideal treatment shall be individualised, achieving optimal glycemic control while minimising the risk of hypoglycemia. Basal-bolus insulin regimen has been recommended as a more physiological, safe and effective way in managing inpatient hyperglycemia and improving prognosis.

　　【Key words】Inpatient hyperglycemia; Basal-bolus regimen; Insulin aspart; Insulin detemir