病例分析

　　【摘要】 目的 分析6例暴发性l型糖尿病(F1D)的临床资料。 方法 报告2001年1月至2012年12月于复旦大学附属华山医院治疗的6例F1D患者资料。 结果 本组病例以起病急骤和严重DKA为特征，平均病程4.83 d，入院时平均血糖42.22 mmol/L，平均HbA1c 6.58%，平均FC-P、2 hC-P分别为0.05、0.08 pmol/L;随访9~72个月后复查胰岛β细胞功能无改善。 结论 F1D起病急骤、代谢紊乱严重，胰岛β细胞功能受损严重且预后差，应引起重视。

　　【关键词】暴发性1型糖尿病;糖化血红蛋白;糖尿病酮症酸中毒

　　【Abstract】 Objective To analyze the clinical data of six cases of fulminant type 1 diabetes mellitus (F1D). Methods To report clinical and laboratory data of six patients diagnosed as F1D in huashan hospital from 2001 to 2012. Results This disease was characterized by abrupt onset and severe diabetic ketoacidosis.The mean duration from the appearance of hyperglycemic symptoms to first hospital visit was 4.83 d.The mean plasma glucose level was 42.22 mmol/L, and the mean value of HbAlc level was 6.58% at first visit.The mean FC-P and 2 hC-P were 0.05, 0.08 pmol/L at onset. β-cell function did not recover after nine to seventy two months of follow-up. Conclusion F1D patients had clinical feathers of abrupt onset, serious metabolic disorders, serious impaired islet β-cell function, poor prognosis, which required special attention by all medical practitioner.

　　【Key words】Fulminant type 1 diabetes mellitus (F1D);Hemoglobin A1c (HbA1c);Diabetic kdtoacidosis (DKA)