·糖尿病神经病变·

　　【摘要】 目的 观察甲钴胺联合加巴喷丁或普瑞巴林治疗痛性糖尿病周围神经病变(PDN)的效果以及安全性。 方法 60例PDN患者根据随机数字表法分为甲钴胺联合加巴喷丁组(n=29),给予甲钴胺和加巴喷丁900 mg/d口服。甲钴胺联合普瑞巴林组(n=31)，予甲钴胺和普瑞巴林150 mg/d口服，疗程均为42 d。用视觉模拟量表(VAS)评分进行临床疗效判定，观察药物不良反应。 结果 两组治疗后VAS评分均较治疗前下降(P<0.05);甲钴胺联合普瑞巴林组治疗前为(7.28±1.34)分，治疗后为(3.98±1.56)分;甲钴胺联合加巴喷丁组治疗前为(7.49±1.67)分，治疗后为(2.14±1.67)分，两组比较差异有统计学意义(P<0.05)，且均未出现严重药物不良反应。 结论 甲钴胺联合普瑞巴林较甲钴胺联合加巴喷丁治疗PDN更有效。

　　【关键词】 糖尿病周围神经病变，痛性;加巴喷丁;普瑞巴林;甲钴胺

Comparative study of curative effect between metcobalamin combined with gabapentin and pregabalin on painful diabetic neuropathy ZONG Hai-jun，TANG Mei. Department of Endocrinology, 2nd Affiliated Hospital of Suzhou University, Suzhou 215004, China

　　【Abstract】 Objective To observe the efficacy and safety of mecobalamin combined with gabapentin (GBP) and pregabalin (PGB) in the treatment of painful diabetic neuropathy (PDN).　Methods Sixty patients with PDN were randomly divided into the gabapentin group(n=29) and pregabalin group(n=31). The gabapentin group was treated with gabapentin 900 mg/d and metcobalamin by oral administration and the pregabalin group were treated by pregabalin 150 mg/d and metcobalamin by oral administration. The course of treatment was 42 d for each group. The efficacy was measured by visual analogue scale(VAS), while the side effects were recorded. Results A significant reduction in VAS score was found in two groups after treatment as compared to pre-treatment [pregabalin group(3.98±1.56) vs (7.28±1.34) score, gabapentin group(2.14±1.67) vs (7.49±1.67) score，all P<0.05]. And there was a significant difference in VAS score between two groups. Side effects were mild in all cases. Conclusion Mecobalamin combined with GBP or PGB relieved the symptoms and signs of PDN significently, and PGB was more effect.

　　【Key words】 Diabetic neuropathies， painful; Gabapentin; Pregabalin;Mecobalamin