【摘要】 T1DM主要是由T淋巴细胞介导的免疫损伤,进而导致胰岛b细胞的短缺。为治愈T1DM，过去25年来，针对如何控制自身免疫，各国学者已对众多方案(如多种单抗阻断和疫苗)进行了探索和临床尝试，多数已失败告终。其根本原因是由于 T1DM的自身免疫反应具有多克隆特性，且具有多重的免疫调节紊乱。近年来，基础和临床研究发现干细胞除了具有分化特性外，还具有重要的免疫调节作用。为T1DM和其他自身免疫的治疗提供了新的手段。在此，将主要介绍我们实验室并创建的Stem Cell Educator治疗技术在T1DM的应用。该技术通过脐血多能干细胞(CB-SC)的免疫调节，可控制自身免疫，再生胰岛b细胞，改善代谢，为 T1DM的治疗开辟了崭新的途径。

　　【关键词】 糖尿病，1型;Stem Cell Educator

　　New Hope for Type 1 Diabetics: Stem Cell Educator Therapy Yong Zhao. University of Illinois at Chicago, Section of Endocrinology and Diabetes, Chicago, IL USA

　　【Abstract】 The global prevalence of diabetes seriously challenges human heath. Type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease that causes the deficit of pancreatic islet b cells. While daily insulin injections offer some control over blood sugar levels，insulin therapy is not a cure. Due to the polyclonal nature and multiple immune dysfunctions in T1DM patients, a true cure has proven elusive despite intensive research pressure by using conventional approaches over the past 25 years. It is essential how to control the autoimmunity of T1DM. Recently, increasing evidence demonstrates that stem cells display the immune modulation in addition to the cellular differentiations. We identified a novel type of stem cells from human cord blood, designated cord blood-derived multipotent stem cells (CB-SC). We also established an innovative technology: the Stem Cell Educator therapy. Animal studies and clinical trials have confirmed that treatment with the Stem Cell Educator (CB-SC) provides lasting reversal of autoimmunity that allows regeneration of islet b cells and improvement of metabolic control in long-standing T1DM subjects，and open up a new avenue to find a cure for T1DM.

　　【Key words】 Diabetes mellitus, type 1; Stem Cell Educator