·糖尿病临床研究·

　　【摘要】 目的 观察T2DM合并乙肝肝硬化患者的不同HbA1c水平的血清细胞因子的变化。 方法 入选T2DM合并肝硬化患者65例，根据HbA1c水平分为血糖控制良好组及控制欠佳组，检测两组血清IL-2、IL4、IL-6、IL-8、IL-10、INF-γ、TNF-α水平。 结果 控制良好组血清细胞因子IL-2、TNF-α[(42.7±20.5) pg/ml、(30.5±20.2) ng/ml]低于控制欠佳组[(58.2±23.8)pg/ml、(43.5±33.7)ng/ml)],控制良好组IL-4、IL-6、IL-8水平[(3.2±1.1)、(7.1±3.7)、(58.3±50.8)pg/ml]高于控制欠佳组[(1.1±0.5)、(3.0±1.3)、(35.5±17.6)pg/ml，P<0.05]。血清IL-8、INF-γ水平两组间差异无统计学意义(P>0.05)。 结论 T2DM合并乙肝肝硬化患者良好血糖控制良好组对比血糖控制欠佳组，Th1和Th2细胞因子差异明显，其意义有待进一步探究。

　　【关键词】 乙型肝炎病毒，肝硬化; 糖尿病，2型;细胞因子

Effect and its clinical significance of glycosylated hemoglobin status on serum cytokine levels of type 2 diabetes patients combined with hepatitis B virus related liver cirrhosis CHEN Jie , XU Bin, HUI Wei, et al. Department of Endocrinology and Hepatology, Youan Hospital,Capital medical university, Beijing 100069 , China

　　【Abstract】 Objective To investigate the effect of serum cytokine levels in T2DM patients combined with HBV-liver cirrhosis With different glycosylated hemoglobin levels. Methods Sixty-five T2DM patients with liver cirrhosis were recruited and divided into good group ( HbA1c 6.5%，n=38) and poor group ( HbA1c>6. 5%， n=27). The serum levels of IL-2,IL4,IL-6,IL-8,IL-10,INF-γ and TNF-α were tested. Results The serum levels of IL-2 and TNF-αwere higher in good control group [(42.7±20.5) pg/ml,(30.5±20.2) ng/ml] than in poor control group [(58.2±23.8)pg/ml,(43.5±33.7)ng/ml]. The serum levels of IL4,IL-6,IL-8 were lower in good control group [(3.2±1.1),(7.1±3.7),(58.3±50.8)pg/ml]than in poor control group [(1.1±0.5),(3.0±1.3),(35.5±17.6)pg/ml,P<0.05]. Conclusion Good control blood glucose status can balance the cytokine network in hepatitis B virus-related cirrhosis patients.

　　【Key words】 Hepatitis B virus, liver cirrhosis;Diabetes mellitus， type 2; Cytokine