【摘要】 目的 探讨糖尿病足溃疡(DFU)感染多重耐药铜绿假单胞菌(MDRPA)的危险因素及其对预后影响。 方法 将117例DFU感染铜绿假单胞菌(PA)患者根据是否感染MDRPA分为两组，分析DFU感染MDRPA的危险因素及其对预后影响。 结果 入院前抗生素应用史、入院前因同一溃疡住院史和骨髓炎是DFU患者感染MDRPA的独立危险因素。MDRPA组截肢/趾率高(32.6% vs 16.2%，P<0.05)，治愈率低(20.9% vs 41.9%，P<0.05)。 结论 入院前抗生素应用史、入院前因同一溃疡住院史和骨髓炎是DFU患者感染MDRPA的独立危险因素。MDRPA可导致创面预后差，增加截肢/趾风险。

　　【关键词】糖尿病足溃疡;感染;多重耐药铜绿假单胞菌;危险因素

　　【Abstract】 Objective To determine the risk factors of diabetic foot ulcer (DFU) with multi-drug resistant Pseudomonas aeruginosa (MDRPA) and the influence of MDRPA to the prognosis of DFU. Methods 117 DFU patients who infected with Pseudomonas aeruginosa (PA) hospitalized were divided into two groups according to the infection of MDRPA, risk factors of DFU infected by MDRPA were analyzed, and also the effect of MDRPA to the prognosis of DFU. Results Previous duration of antibiotic therapy, previous hospitalization for the same wound and osteomyelitis were independent risk factors of DFU infected by MDRPA. Compared with non-MDRPA group, MDRPA had a higher amputation/toe rate (32.6% vs 16.2%, P<0.05), lower cure rate (20.9% vs 41.9%, P<0.05). Conclusion Previous duration of antibiotic therapy, previous hospitalization for the same wound and osteomyelitis were independent risk factors of DFU infected by MDRPA. MDRPA infection often lead to a poor prognosis, and increased the risk of amputation / toe in DFU patients.

　　【Keywords】Diabetic foot ulcer (DFU);Infection;Multi-drug resistant Pseudomonas aeruginosa (MDRPA);Risk factors