糖尿病临床研究•

　　【摘要】 目的 分析超声定量检测T2DM患者肝脏脂肪含量(LFC)和各临床资料及血脂组分的相关性。 方法 采用超声定量检测306例住院T2DM患者LFC，分别记录性别、年龄、体重、BMI、WC、臀围(HC)、WHR及病程等临床资料，并检测TC、TG、HDL-C、LDL-C，根据LFC三分位分为Q1～Q3组，分析其与各临床资料及血脂组分的相关性。 结果 随LFC增加，各组体重、BMI、WC、HC、WHR、TG均逐步增加，而年龄和病程逐步递减(P<0.05)。校正性别、年龄、BMI后，偏相关分析显示，LFC与TG呈线性正相关(r=0.216，P=0.000)。 结论 T2DM患者超声定量检测LFC对非酒精性脂肪肝诊治有一定的临床应用价值，其与体重、BMI、WC、HC、WHR有关，与血清TG水平呈正相关。

　　【关键词】 糖尿病，2型;超声;肝脏脂肪含量

　　【Abstract】 Objective To analyze the correlation between liver fat content (LFC) which measured by ultrasonic quantitation and clinical data, blood lipid composition in patients with T2DM. Methods Ultrasonic quantitative detection of LFC was performed in 306 hospitalized patients with T2DM, and gender, age, weight, BMI, waist circumference, hip circumference, waist-to-hip ratio and course were recorded. The serum level of TC, TG, HDL-C, LDL-C were detected. All subjects were divided into Q1～Q3 groups according to tertiles of LFC. Correlation between LFC and clinical data, blood lipid composition were analyzed among three groups. Results With the increase of LFC, index such as body weight, BMI, waist circumference, hip circumference, waist-to-hip ratio, TG were gradually increased, while age and course of the disease were gradually decreased (P<0.05). After correction for gender, age and BMI, partial correlation analysis that LFC was linear positive associated with TG(r=0.216，P=0.000). Conclusion In patients with T2DM, Ultrasonic quantitative detection of LFC has higher clinical value to diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD), and it is correlated with weight, BMI, waist circumference, hip circumference and waist-to-hip ratio. Besides, LFC was obviously linear positive correlated with TG.

　　【Key words】 Diabetes mellitus， type 2;Ultrasound;Liver fat content