·HbA1c测定和应用·

　　【摘要】 目的 对我国临床HbA1c检测仪器的相关情况进行调查。方法 由中华医学会糖尿病学分会“糖化血红蛋白监测网”项目组于2011年7至9月在全国范围内选择具有代表性的606家医院进行横断面研究，以问卷调查形式,收集用于检测HbA1c仪器型号、测定方法及正常值参考范围，并对结果进行统计分析。 结果 HbA1c检测仪器种类繁多，最常用的检测方法是离子交换高效液相色谱法(HPLC,219，37.2%)。各实验室的正常值参考范围存在一定差异，低值的分布范围0%~10.1%，高值的分布范围1.3%~33.1%。有202家(34.6%)医院实验室HbA1c正常值参考范围上限≥6.5%。 结论 我国HbA1c检测方法需进一步规范以为临床糖尿病诊疗提供可靠的决策依据。

　　【关键词】糖化血红蛋白;检测仪器;正常值参考范围

National survey of HbA1c measurements in 2011 LIU Wei, JI Li-nong. Department of Endocrinology, Peking University People's Hospital, Beijing 100044, China

　　【Abstract】Objective To investigate the basic information of clinically used HbA1c instruments in China. Methods Using questionnaires to get the HbA1c instrument models, detection methods, and reference ranges of indices of 606 clinical laboratories selected from all around China by the Chinese Diabetes Society, Chinese Medical Society, from July to September 2011. All the questionnaires were gathered and the results were analyzed statistically. Results Various kinds of HbA1c instruments are now in clinical use in China, and the most widely used method is iron-exchange high performance liquid chromatography (HPLC) (219, 37.2%). There are still some differences in reference range among these laboratories with the lower limit from 0% to 10.1% and upper limit from 1.3% to 33.1%. And the 202 (34.6%) laboratories have the upper limit≥6.5%. Conclusions The HbA1c measurement is still at the initial stage in China. In order to provide credible diagnostic reference for clinical application, we need to strengthen the quality control management and standardize the HbA1c detection.

　　【Key words】Hemoglobin A1c (HbA1c); HbA1c instruments; Reference range