·糖尿病与大血管病·

　　【摘要】 目的 探讨T2DM患者尿白蛋白排泄率(UAER)与肱踝脉搏波(baPWV)的相关性。 方法 202例T2DM患者检测HbA1c、血糖、血脂、血压、肾功能、UAER，计算BMI，欧姆龙-科林动脉硬化检测仪测定baPWV;根据UAER水平从低到高为4组，根据UAER的四分位数分为Q1组(0～2.50 μg/min)、Q2组(2.50～6.05 μg/min)、Q3组(6.05～18.07 μg/min)组和Q4组(18.07～180.60 μg/min)，分析UAER与baPWV之间的关系及变化趋势。 结果 baPWV随UAER水平的增加而增快(P<0.01)。Pearson相关分析示UAER与baPWV呈正相关(r=0.30，P<0.01)，多因素回归分析示UAER进入baPWV为因变量的回归方程(P<0.05)。 结论 T2DM患者UAER与baPWV关系密切。

　　【关键词】糖尿病，2型;尿白蛋白;脉搏波传导速度

Correlation between urinary albumin excretion and brachial-ankle pulse wave velocity in T2DM JING Yuan, YAO Xia, CUI Kai, et al. Shengli Oilfield Central Hospital, Dongying 257034, China

Corresponding author: CHEN Qi-cai, E-mail: cqc136@163.com

　　【Abstract】Objective To investigate the correlation between urinary albumin excretion (UAER) and brachial-ankle pulse wave velocity (baPWV) in T2DM. Methods The HbA1c, blood glucose, blood lipid, blood pressure, renal functions, and UAER of 202 subjects with T2DM were determined, their BMI was calculated, and their baPWV was tested using Omron atherosclerosis detector. The subjects were divided into four groups according to UAER quartiles from low to high, Q1 group (0～2.50 μg/min), Q2 group (2.50～6.05 μg/min), Q3 group (6.05～18.07 μg/min), and Q4 group (18.07～180.60 μg/min). The contribution of UAER to baPWV was determined by multivariate liner regression analysis. Results The baPWV gradually elevated along with UAER increasing (P<0.01). Pearson analysis showed that UAER was positively correlated with baPWV (r=0.30, P<0.01). Multivariate liner regression analysis also showed that UAER was positively correlated with baPWV (P<0.05). Conclusions The level of UAER is closely correlated with baPWV in T2DM.

　　【Key words】Diabetes mellitus, type 2; Albuminuria; Brachial-ankle pulse wave velocity