·糖尿病与大血管病变·

　　【摘要】 目的 探讨T2DM患者踝臂指数(ABI)、趾肱指数(TBI)和肱踝脉搏波速度(baPWV)改变及相关危险因素。方法 测定研究对象ABI、TBI及baPWV实验室及人体测量学指标，进行分析比较。 结果 与对照组相比，糖尿病组baPWV显著升高/TBI显著降低，差异有统计学意义(P<0.05)。年龄是ABI和TBI异常的相关危险因素，年龄、DBP、2 hPG和HbA1c是baPWV异常的相关危险因素，高密度脂蛋白是TBI的保护因素。结论 动脉硬化检测可评价糖尿病患者动脉弹性，积极控制血压和血糖可延缓动脉硬化进程。

　　【关键词】 糖尿病,2型;踝臂指数;肱踝脉搏波传导速度;趾臂指数

Changes of ABI, PWV, and TBI and their influencing factors for T2DM patients DONG Xiao-yun, ZHANG Lei, LI Juan-juan, et al. Qingdao Indocrine and diabetes Hospital, Qingdao 266071, China

Corresponding author: DONG Yan-hu, E-mail: dongyh@public.qd.sd.cn

　　【Abstract】 Objective To investigate the changes in ankle-brachial index (ABI), toe brachial index (TBI), and brachial-ankle pulse wave velocity (baPWV) and their related risk factors for the T2DM patients. Methods The baPWV, ABI, TBI, laboratory and anthropometric indicators of the subjects were measured and analyzed. Result Compared with the control group, the baPWV significantly increased, and the TBI significantly decreased in the diabetic group, and the difference was of statistical significance (P<0.05). Age was the risk factor of ABI and TBI abnormalities. Age, DBP, 2 hPG, and HbA1c were the risk factors of baPWV abnormality. And HDL was a protective factor of TBI (P<0.05). Conclusion Arteriosclerosis detection can evaluate arterial elasticity in diabetic patients. Active control of blood pressure and blood glucose can slow down the atherosclerosis process.

　　【Key words】Diabetes mellitus, type 2; Ankle-brachial index (ABI); Brachial-ankle pulse wave velocity (baPWV); Toe-brachial index (TBI)