来自:中国糖尿病杂志 编辑:张军 韩旸 李洪梅|点击数:|2013-07-18
·病例报告·
【摘要】 患者女,59岁,主因“乏力2 d、恶心、呕吐1 d”入院。13年前诊断为干燥综合征。入院后查尿酮体+++,血pH 7.018,随机FPG 48.02 mmol/L,HbA1c 8.6%,谷氨酸脱羧酶抗体(GADAb)、胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA)均为阴性,诊断为糖尿病酮症酸中毒(DKA)、暴发性1型糖尿病(F1D),经补液及胰岛素治疗,酮症消除,血糖控制良好。
【关键词】 糖尿病;干燥综合征;自身免疫
Fulminant type 1 diabetes mellitus accompanied with Sjogren's Syndrome— A report on one case ZHANG Jun, HAN Yang, LI Hong-mei. Department of Endocrinology, China Meitan General Hospital, Beijing 100028, China
【Summary】A 59-years-old female complained of weakness for 2 days and nausea and emesis for 1 day before hospitalization. She was diagnosed Sjogren's Syndrome 13 years before. Her urinary ketobody was +++ positive, blood pH was 7.018,and her random blood glucose was 48.02mmol/l, while the HbA1c was only 8.6%, and the glutamic acid decarboxylase antibody (GADAb), islet cellular antibody (ICA),insulin autoantibody (IAA) of her serum were all negative. Her diagnosis was diabetic ketoacidosis and fulminant type 1 diabetes mellitus (FT1DM). With treatment of fluid infusion and insulin, her ketoacidosis was eliminated and blood glucose was controlled well. FT1DM customarily has no relationship with autoimmunity, and there is no report on FT1DM combined with Sjogren's Syndrome before.
【Keywords】Diabetes mellitus; Sjogren's Syndrome; Autoimmunity
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